Contribution of semaphorins to the formation of the peripheral nervous system in higher vertebrates.

Contribution of semaphorins to the formation of the peripheral nervous system in higher vertebrates.
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DOI:
10.1080/19336918.2016.1243644
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发表时间:
2016-11
影响因子:
3.2
通讯作者:
Taniguchi M
Taniguchi M
中科院分区:
生物学3区
文献类型:
--
作者:
Masuda T;Taniguchi M

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脑信号蛋白是一个以sema结构域为特征的蛋白质大家族,不仅在神经回路的形成中,而且在免疫系统、血管生成、肿瘤进展和骨代谢中发挥关键作用。迄今为止,已经报道了15种信号蛋白参与高等脊椎动物外周神经系统(PNS)的形成。许多实验已经揭示了它们在PNS中的功能,其中它们主要作为轴突引导线索(作为驱避剂或引诱剂)。脑信号蛋白在PNS神经元的迁移和感觉-运动连接的形成中也起重要作用。本文就高等脊椎动物脑信号蛋白在PNS形成中的作用作一综述。
Semaphorins are a large family of proteins characterized by sema domains and play a key role not only in the formation of neural circuits, but in the immune system, angiogenesis, tumor progression, and bone metabolism. To date, 15 semaphorins have been reported to be involved in the formation of the peripheral nervous system (PNS) in higher vertebrates. A number of experiments have revealed their functions in the PNS, where they act mainly as axonal guidance cues (as repellents or attractants). Semaphorins also play an important role in the migration of neurons and formation of sensory-motor connections in the PNS. This review summarizes recent knowledge regarding the functions of higher vertebrate semaphorins in the formation of the PNS.
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