Prevalence of posterior staphyloma and factors associated with its shape in the Japanese population.
Prevalence of posterior staphyloma and factors associated with its shape in the Japanese population.
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DOI：
10.1038/s41598-018-22759-y
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发表时间：
2018-03-15
影响因子：
4.6
通讯作者：
Tsujikawa A
中科院分区：
文献类型：
--
作者：
Numa S;Yamashiro K;Wakazono T;Yoshikawa M;Miyake M;Nakanishi H;Oishi A;Nagahama Study Group;Tabara Y;Matsuda F;Yoshimura N;Tsujikawa A
近视在全球范围内迅速增长。我们进行了一项横断面研究，以调查日本社区队列中近视并发症--后葡萄肿的患病率及其形状特征与年龄、性别和眼轴长度(AL)的关系。对3748名接受眼底摄影和光学相干断层扫描(OCT)检查的受试者的右眼进行了评估。使用眼底照片和OCT图像评估后部葡萄肿的患病率。在此基础上，每隔1 µm测量6 mm交叉线OCT图像上的局部眼底曲率，并计算其均值和方差来代表每只眼的眼底形态，以研究眼底曲率与年龄、性别和AL的关系。后部葡萄肿77眼(2.05%)。女性眼底曲度的均值和方差明显大于男性，且随年龄增长而增大，提示女性和老年受试者的葡萄肿形状更陡峭，更不光滑。AL与平均曲率呈显著相关(P = 2 × 10−16，R = 0.480)，且受年龄的影响显著(P <； 2 × 10−16)。眼底形态的定量分析有助于统计分析后葡萄肿与年龄、性别和AL的关系。
Myopia is increasing rapidly worldwide. We performed a cross-sectional study to investigate the prevalence of posterior staphyloma, a complication of myopia, and its shape characteristics in relation to age, sex, and axial length (AL) in a Japanese community-based cohort. The right eyes of 3748 participants who underwent fundus photography and optical coherence tomography (OCT) examination were evaluated. Posterior staphyloma prevalence was evaluated using fundus photographs and OCT images. Furthermore, fundus shapes were analyzed by measuring local fundus curvatures on 6 mm cross-line OCT images at intervals of 1 µm. The mean and variance of the curvatures were calculated to represent the fundus shape of each eye for investigation of the relationship between fundus curvature and age, sex, and AL. Seventy-seven eyes (2.05%) had posterior staphyloma. The mean and variance of the fundus curvatures were significantly greater in women than in men and became greater with age, suggesting that the shape of the staphyloma was steeper and less smooth in women and elderly subjects. AL and mean curvature showed a significant correlation (P = 2 × 10−16, R = 0.480), which was significantly affected by age (P < 2 × 10−16). Quantitative analysis of fundus shapes was useful for statistical analysis of posterior staphyloma in relation to age, sex, and AL.
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影响因子：
13.7
作者：
Iwase, Aiko;Araie, Makoto;Kitazawa, Yoshiaki
通讯作者：
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Chou, P
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13.7
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影响因子：
4.2
作者：
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通讯作者：
Wong, Tien Yin