Altered functional connectivity of the thalamus in patients with insomnia disorder after transcutaneous auricular vagus nerve stimulation therapy.
Altered functional connectivity of the thalamus in patients with insomnia disorder after transcutaneous auricular vagus nerve stimulation therapy.
复制标题
经皮耳迷走神经刺激治疗后失眠患者丘脑功能连通性的改变。
DOI：
10.3389/fneur.2023.1164869
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发表时间：
2023
影响因子：
3.4
通讯作者：
中科院分区：
文献类型：
--
作者：
失眠的发病机制与丘脑功能紊乱有关。经皮耳迷走神经刺激（taVNS）已被证明是有效的治疗失眠。然而，taVNS是否通过调节丘脑相关的功能连接来减轻失眠仍不清楚。为了阐明taVNS对丘脑静息态功能连接（RSFC）的即时调节作用，招募了20例失眠症患者接受taVNS治疗，并在刺激前后立即收集其静息态功能磁共振成像（fMRI）数据。将fMRI数据与20名年龄和性别匹配的健康受试者进行比较，这些受试者没有接受刺激，只收集了一次RSFC fMRI数据。在两组中进行丘脑的RSFC分析。除了评估ID患者和健康对照之间关于丘脑RSFC的组差异之外，我们还检查了ID患者中taVNS诱导的丘脑RSFC的变化。在taVNS治疗前，ID患者表现出丘脑与右侧额下回和额下回的RSFC比健康对照组增加。taVNS治疗后，患者丘脑与右侧角回、左侧扣带回前部和楔前叶之间的RSFC显著降低。这项研究提供了对失眠症患者进行的taVNS涉及丘脑相关功能连接的即时脑效应的见解。
The pathogenesis of insomnia is related to the dysfunction of the thalamus. Transcutaneous auricular vagus nerve stimulation (taVNS) has proved to be effective in treating insomnia. However, whether taVNS alleviates insomnia through modulating thalamus-related functional connectivity remains unclear. To elucidate the instant modulating effects of taVNS on the resting state functional connectivity (RSFC) of the thalamus, 20 patients with insomnia disorder were recruited to receive taVNS treatment and their resting state functional magnetic resonance imaging (fMRI) data were collected immediately before and after stimulation. The fMRI data were compared with 20 age- and gender-matched healthy subjects who received no stimulation and had RSFC fMRI data collected once. RSFC analyses of the thalamus were performed in both groups. In addition to assessing the group differences between ID patients and healthy controls regarding the RSFC of the thalamus, we examined the taVNS-induced changes of RSFC of the thalamus in ID patients. Before taVNS treatment, the ID patients showed increased RSFC of the thalamus with the right insula and inferior frontal gyrus than healthy controls. After taVNS treatment, the RSFC between the thalamus and the right angular gyrus, left anterior cingulate gyrus, and precuneus were significantly decreased in patients. This study provides insights into the instant brain effects involving the thalamus-related functional connectivity of taVNS performed on insomnia disorder patients.
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影响因子：
2.6
作者：
Chen, Michael C.;Chang, Catie;Glover, Gary H.;Gotlib, Ian H.
通讯作者：
Gotlib, Ian H.
纵向穿迷走神经刺激治疗抑郁症的早期皮质生物标志物。
DOI：
10.1016/j.nicl.2016.12.016
发表时间：
2017
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Fang J;Egorova N;Rong P;Liu J;Hong Y;Fan Y;Wang X;Wang H;Yu Y;Ma Y;Xu C;Li S;Zhao J;Luo M;Zhu B;Kong J
通讯作者：
Kong J
影响因子：
5.7
作者：
Roehrs, Timothy;Roth, Thomas
通讯作者：
Roth, Thomas
影响因子：
3.1
作者：
Menon, Vinod;Uddin, Lucina Q.
通讯作者：
Uddin, Lucina Q.
DOI：
10.1080/17425255.2018.1483338
发表时间：
2018-01-01
影响因子：
4.3
作者：
Huang, Zhibin;Xu, Zhiru;Rao, Yulan
通讯作者：
Rao, Yulan