Expression and characterization of αvβ5 integrin on intestinal macrophages.
Expression and characterization of αvβ5 integrin on intestinal macrophages.
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DOI：
10.1002/eji.201747318
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发表时间：
2018-07
影响因子：
5.4
通讯作者：
Mowat AM
中科院分区：
文献类型：
--
作者：
Kumawat AK;Yu C;Mann EA;Schridde A;Finnemann SC;Mowat AM
巨噬细胞在维持肠道内动态平衡方面起着至关重要的作用，但其潜在的机制尚未完全阐明。在这里，我们首次展示了小鼠肠道中成熟的肠巨噬细胞表达高水平的αvβ5整合素，它作为一种受体摄取凋亡细胞，并可以激活参与组织稳态的多个方面的分子，如血管生成和细胞外基质的重塑。αvβ5在肠道其他免疫细胞中不表达，出生后不久就存在于肠道巨噬细胞上，其表达不依赖于微生物区系。在成人中，αvβ5是在单核细胞对局部环境的反应中被诱导的，它使肠道巨噬细胞有能力通过参与桥接分子乳脂球EGF样分子8来促进凋亡细胞的吞噬。在没有αvβ5的情况下，粘膜中的单核细胞较少，成熟的肠巨噬细胞金属蛋白酶和IL 10的表达减少。缺乏αvβ5的小鼠对化学性结肠炎的易感性增加，我们得出结论，αvβ5通过调节肠道巨噬细胞的动态平衡特性而促进组织修复。
Macrophages play a crucial role in maintaining homeostasis in the intestine, but the underlying mechanisms have not yet been elucidated fully. Here, we show for the first time that mature intestinal macrophages in mouse intestine express high levels of αvβ5 integrin, which acts as a receptor for the uptake of apoptotic cells and can activate molecules involved in several aspects of tissue homeostasis such as angiogenesis and remodeling of the ECM. αvβ5 is not expressed by other immune cells in the intestine, is already present on intestinal macrophages soon after birth, and its expression is not dependent on the microbiota. In adults, αvβ5 is induced during the differentiation of monocytes in response to the local environment and it confers intestinal macrophages with the ability to promote engulfment of apoptotic cells via engagement of the bridging molecule milk fat globule EGF-like molecule 8. In the absence of αvβ5, there are fewer monocytes in the mucosa and mature intestinal macrophages have decreased expression of metalloproteases and IL 10. Mice lacking αvβ5 on haematopoietic cells show increased susceptibility to chemical colitis and we conclude that αvβ5 contributes to the tissue repair by regulating the homeostatic properties of intestinal macrophages.
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DOI：
10.1084/jem.20041447
发表时间：
2004-12-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Nandrot EF;Kim Y;Brodie SE;Huang X;Sheppard D;Finnemann SC
通讯作者：
Finnemann SC
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
5.3
作者：
Huang, XZ;Griffiths, M;Sheppard, D
通讯作者：
Sheppard, D
DOI：
10.1073/pnas.0704756104
发表时间：
2007-07-17
影响因子：
11.1
作者：
Nandrot, Emeline F.;Anand, Monika;Finnemann, Silvia C.
通讯作者：
Finnemann, Silvia C.
影响因子：
7.3
作者：
Kühl AA;Erben U;Kredel LI;Siegmund B
通讯作者：
Siegmund B