Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice.
Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice.
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从未在肠道中衍生出稳态组织中的巨噬细胞的范式是在肠道中研究的，该肠道中含有最大的巨噬细胞。使用命运图模型和单核减少小鼠，以及骨髓嵌合和抛害生成模型，我们表明胚胎前体播种肠粘膜播种，并在新生儿时期表现出广泛的原位增殖。但是，这些细胞在成年肠内并未持续。取而代之的是，它们在断奶时被CCR2依赖性的Ly6chi单核细胞的流入而替换，这些ly6chi单核细胞分化为成熟的抗炎巨噬细胞。这个过程主要由菌群驱动，并且必须在整个成年生活中继续保持正常的肠道巨噬细胞。
The paradigm that resident macrophages in steady-state tissues are derived from embryonic precursors has never been investigated in the intestine, which contains the largest pool of macrophages. Using fate mapping models and monocytopenic mice, together with bone marrow chimeric and parabiotic models, we show that embryonic precursors seeded the intestinal mucosa and demonstrated extensive in situ proliferation in the neonatal period. However these cells did not persist in adult intestine. Instead, they were replaced around the time of weaning by the CCR2-dependent influx of Ly6Chi monocytes that differentiated locally into mature, anti-inflammatory macrophages. This process was driven largely by the microbiota and had to be continued throughout adult life to maintain a normal intestinal macrophage pool.
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Langerhans细胞（LC）增殖介导了新生儿发育，体内平衡和与表皮LC网络的炎症相关扩张。
DOI：
10.1084/jem.20091586
发表时间：
2009-12-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chorro L;Sarde A;Li M;Woollard KJ;Chambon P;Malissen B;Kissenpfennig A;Barbaroux JB;Groves R;Geissmann F
通讯作者：
Geissmann F
DOI：
10.1084/jem.20120340
发表时间：
2012-06-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hoeffel G;Wang Y;Greter M;See P;Teo P;Malleret B;Leboeuf M;Low D;Oller G;Almeida F;Choy SH;Grisotto M;Renia L;Conway SJ;Stanley ER;Chan JK;Ng LG;Samokhvalov IM;Merad M;Ginhoux F
通讯作者：
Ginhoux F
DOI：
10.1084/jem.20072168
发表时间：
2008-05-12
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Benz C;Martins VC;Radtke F;Bleul CC
通讯作者：
Bleul CC
影响因子：
3.2
作者：
Nagashima, R;Maeda, K;Takahashi, T
通讯作者：
Takahashi, T
影响因子：
30.5
作者：
Liu, Kang;Waskow, Claudia;Nussenzweig, Michel
通讯作者：
Nussenzweig, Michel