Genetic structure of phenotypic robustness in the collaborative cross mouse diallel panel.
Genetic structure of phenotypic robustness in the collaborative cross mouse diallel panel.
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DOI：
10.1111/jeb.12906
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发表时间：
2016-09
影响因子：
2.1
通讯作者：
Hallgrímsson B
中科院分区：
文献类型：
--
作者：
Gonzalez PN;Pavlicev M;Mitteroecker P;Pardo-Manuel de Villena F;Spritz RA;Marcucio RS;Hallgrímsson B
发育稳定性和渠化描述了发育系统在面对随机微环境效应、遗传变异和环境影响时将表型变异最小化的能力。渠化是将遗传或环境影响的影响降到最低的能力，而发育稳定性是将个体内部微环境影响的影响降到最低的能力。尽管受到很多关注，但表型稳健性的这两个组成部分的机制仍然未知。我们研究了协作杂交（CC）小鼠参考群体中表型稳健性的遗传结构。采用几何形态计量学和基于贝叶斯方法的双列分析方法，分析了8个亲本株系在正交中颅形的波动不对称（FA）大小和个体间变异。尽管在个体水平上相关性较差，但两种测量方法的基因型之间存在显著差异。近交对变异的两个组成部分都有总体的积极影响。菌株CAST/EiJ对FA有正的加性效应，对个体方差有较小的加性效应。性别和其他菌株特异性影响不显著。FA和个体间变异均与表型极端化无关。我们的研究结果支持遗传变异在发育稳定性和管道化方面的存在。这一发现很重要，因为健壮性是发育系统的一个关键特征。我们发现稳健性与表型极端无关，这与理论工作一致，理论工作表明稳健性与稳定选择的关系并不直接。
Developmental stability and canalization describe the ability of developmental systems to minimize phenotypic variation in the face of stochastic micro-environmental effects, genetic variation and environmental influences. Canalization is the ability to minimize the effects of genetic or environmental effects, while developmental stability is the ability to minimize the effects of micro-environmental effects within individuals. Despite much attention, the mechanisms that underlie these two components of phenotypic robustness remain unknown. We investigated the genetic structure of phenotypic robustness in the Collaborative Cross (CC) mouse reference population. We analyzed the magnitude of fluctuating asymmetry (FA) and among-individual variation of cranial shape in reciprocal crosses among the eight parental strains, by using geometric morphometrics and a diallel analysis based on a Bayesian approach. Significant differences among genotypes were found for both measures, though they were poorly correlated at the level of individuals. An overall positive effect of inbreeding was found for both components of variation. The strain CAST/EiJ exerted a positive additive effect on FA and, to a lesser extent, among-individual variance. Sex and other strain specific effects were not significant. Neither FA nor among-individual variation was associated with phenotypic extremeness. Our results support the existence of genetic variation for both developmental stability and canalization. This finding is important because robustness is a key feature of developmental systems. Our finding that robustness is not related to phenotypic extremeness is consistent with theoretical work that suggests that its relationship to stabilizing selection is not straightforward.
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影响因子：
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