Comparative effects of mercury chloride and methylmercury exposure on early neurodevelopment in zebrafish larvae.
Comparative effects of mercury chloride and methylmercury exposure on early neurodevelopment in zebrafish larvae.
复制标题
氯化汞和甲基汞暴露对斑马鱼幼虫早期神经发育的比较影响
作者：
Mercury (Hg) is a ubiquitous environmental toxicant with important public health implications. Hg causes neurotoxicity through astrocytes, Ca2+, neurotransmitters, mitochondrial damage, elevations of reactive oxygen species and post-translational modifications. However, the similarities and differences between the neurotoxic mechanisms caused by different chemical forms of Hg remain unclear. Zebrafish embryos were exposed to methylmercury (MeHgCl) or mercury chloride (HgCl2) (0, 4, 40, 400 nM) up for 96 h. HgCl2 exposure could significantly decrease survival rate, body length and eye size, delay the hatching period, induce tail bending and reduce the locomotor activity, and these effects were aggravated in the MeHgCl group. The compounds could increase the number of apoptotic cells in the brain and downregulate the expression of Shha, Ngn1 and Nrd, which contribute to early nervous development. The underlying mechanisms were investigated by metabolomics data. Galactose metabolism, tyrosine metabolism and starch and sucrose metabolism pathways were disturbed after HgCl2 or MeHgCl exposure. In addition, the levels of three neurotransmitters including tyrosine, dopamine and tryptophan were reduced after HgCl2 or MeHgCl exposure. Oxidative stress is related to metabolite changes, such as changes in the putrescine, niacinamide and uric acid contents in the HgCl2 group, and squalene in the MeHgCl group. These data indicated that downregulation of these genes and abnormal metabolic profile and pathways contribute to the neurotoxicity of HgCl2 and MeHgCl.
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影响因子：
48
作者：
Grandjean, Philippe;Landrigan, Philip J.
通讯作者：
Landrigan, Philip J.
影响因子：
8.9
作者：
Kim, Jin;Oh, Hanseul;Park, Jae-Hak
通讯作者：
Park, Jae-Hak
MEHG诱导的神经毒性的翻译后修饰。
DOI：
10.1016/j.bbadis.2018.10.024
发表时间：
2019-08-01
期刊：
Biochimica et biophysica acta. Molecular basis of disease
影响因子：
--
作者：
Ke T;Gonçalves FM;Gonçalves CL;Dos Santos AA;Rocha JBT;Farina M;Skalny A;Tsatsakis A;Bowman AB;Aschner M
通讯作者：
Aschner M
影响因子：
14.5
作者：
Kim, Artem;Savary, Clara;de Bakker, Paul I. W.
通讯作者：
de Bakker, Paul I. W.
影响因子：
4
作者：
Korbas, Malgorzata;MacDonald, Tracy C.;Krone, Patrick H.
通讯作者：
Krone, Patrick H.