Magnetic resonance imaging measures of decreased aortic strain and distensibility are proportionate to insulin resistance in adolescents with type 1 diabetes mellitus.
Magnetic resonance imaging measures of decreased aortic strain and distensibility are proportionate to insulin resistance in adolescents with type 1 diabetes mellitus.
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DOI：
10.1111/pedi.12241
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发表时间：
2015-03
影响因子：
3.4
通讯作者：
Gidding SS
中科院分区：
文献类型：
--
作者：
McCulloch MA;Mauras N;Canas JA;Hossain J;Sikes KM;Damaso LC;Redheuil A;Ross JL;Gidding SS
确定1型糖尿病（T1 DM）儿童是否有通过磁共振成像（MRI）测量的主动脉僵硬度增加或早期动脉粥样硬化的证据。T1 DM会增加成年人患心血管疾病的风险，但这一过程是否始于儿童时期尚不清楚。共有54名T1 DM患者（15.4 ± 2.6岁）和30名年龄匹配的对照（14.8 ± 2.7岁）参与研究。进行MRI以评估主动脉弓脉搏波速度（PWV）、应变、升主动脉和降主动脉的扩张性以及动脉粥样硬化的测量。各组在年龄、脉压和性别方面匹配良好。T1 DM患者的低密度脂蛋白-胆固醇（LDL-C）较高（119.3 ± 50 vs. 76.1 ± 13.5 mg/dL，p < 0.0001）。与对照组相比，T1 DM组升主动脉（扩张性：T1 DM组62.2 ± 19.9 kPa−1 ×10−3，对照组71.6 ± 26.4 kPa−1 × 10 −3，p = 0.08）和降主动脉（应变：T1 DM组25.8 ± 6.2% vs.对照组28.3 ± 6.8%，p = 0.09）的应变和扩张性有降低的趋势。弓PWV无差异。年龄增长和男性与主动脉僵硬度呈负相关。糖化血红蛋白（HbA 1c）与降主动脉张力和扩张性呈负相关（p < 0.05）。胰岛素敏感性最低的两个三分位数的糖尿病儿童显示胸降支血管具有显著较低的应变（p = 0.027）和扩张性（p = 0.039）以及增加的壁不规则性（p = 0.005）。两组之间动脉粥样硬化的测量结果没有差异。患有T1 DM的青少年，尤其是那些胰岛素敏感性较低的青少年，表现出更僵硬、顺应性更低的胸椎强直趋势，这与糖尿病控制呈负相关。这些数据表明大血管病变在T1 DM早期开始。
To determine whether children with type 1 diabetes mellitus (T1DM) have evidence of increased aortic stiffness or early atherosclerosis as measured by magnetic resonance imaging (MRI). T1DM increases risk for cardiovascular disease in adults but whether this process starts in childhood is unknown. A total of 54 T1DM patients (15.4 ± 2.6 yr) and 30 age-matched controls (14.8 ± 2.7 yr) participated. MRI was performed to assess aortic arch pulse wave velocity (PWV), strain, and distensibility of the ascending and descending thoracic aorta and measures of atherosclerosis. Groups were well-matched for age, pulse pressure, and gender. Low-density lipoprotein-cholesterol (LDL-C) was higher in T1DM (119.3 ± 50 vs. 76.1 ± 13.5 mg/dL, p < 0.0001). There was a trend toward decreased strain and distensibility in T1DM vs. controls in the ascending (distensibility: T1DM 62.2 ± 19.9 kPa−1 ×10−3, control 71.6 ± 26.4 kPa−1 ×10−3, p = 0.08) and descending aorta (strain: T1DM 25.8 ± 6.2% vs. control 28.3 ± 6.8%, p = 0.09). There was no difference in arch PWV. Advancing age and male gender was negatively associated with aortic stiffness. Hemoglobin A1c (HbA1c) was inversely related to descending aorta strain and distensibility (p < 0.05). Children with diabetes in the lowest two tertiles of insulin sensitivity demonstrated thoracic descending aortas with significantly lower strain (p = 0.027) and distensibility (p = 0.039) and increased measures of wall irregularity (p = 0.005). There were no differences in measurements of atherosclerosis between the two groups. Adolescents with T1DM, especially those with lower insulin sensitivity, demonstrated a trend toward stiffer, less compliant thoracic aortas, which was inversely associated with diabetes control. These data suggest large vessel aortopathy starts early in T1DM.
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影响因子：
8.2
作者：
Dabelea D;D'Agostino RB Jr;Mason CC;West N;Hamman RF;Mayer-Davis EJ;Maahs D;Klingensmith G;Knowler WC;Nadeau K
通讯作者：
Nadeau K
DOI：
10.1186/1532-429x-14-77
发表时间：
2012-11-14
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Voges I;Jerosch-Herold M;Hedderich J;Pardun E;Hart C;Gabbert DD;Hansen JH;Petko C;Kramer HH;Rickers C
通讯作者：
Rickers C
影响因子：
5.9
作者：
van Elderen SG;Brandts A;Westenberg JJ;van der Grond J;Tamsma JT;van Buchem MA;Romijn JA;Kroft LJ;Smit JW;de Roos A
通讯作者：
de Roos A
影响因子：
9.3
作者：
Dalla Pozza R;Beyerlein A;Thilmany C;Weissenbacher C;Netz H;Schmidt H;Bechtold S
通讯作者：
Bechtold S
影响因子：
16.2
作者：
Turkbey, Evrim B.;Redheuil, Alban;Bluemke, David A.
通讯作者：
Bluemke, David A.