Aortic stiffness is associated with cardiac function and cerebral small vessel disease in patients with type 1 diabetes mellitus: assessment by magnetic resonance imaging.
Aortic stiffness is associated with cardiac function and cerebral small vessel disease in patients with type 1 diabetes mellitus: assessment by magnetic resonance imaging.
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DOI：
10.1007/s00330-009-1655-4
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发表时间：
2010-05
影响因子：
5.9
通讯作者：
de Roos A
中科院分区：
文献类型：
--
作者：
van Elderen SG;Brandts A;Westenberg JJ;van der Grond J;Tamsma JT;van Buchem MA;Romijn JA;Kroft LJ;Smit JW;de Roos A
利用磁共振成像 (MRI) 评估主动脉脉搏波速度 (PWV) 是否与 1 型糖尿病 (DM) 患者的心脏左心室 (LV) 功能和质量以及脑小血管疾病相关。我们在一项前瞻性横断面研究中纳入了 86 名连续 1 型糖尿病患者（49 名男性，平均年龄 46.9±11.7 岁）。排除标准包括主动脉/心脏病和一般 MRI 禁忌症。对主动脉、心脏和大脑进行 MRI 评估，以评估主动脉 PWV，作为主动脉僵硬度、左心室收缩功能和质量的标志，以及是否存在脑白质高信号 (WMH)、微出血和腔隙性梗塞。采用多变量线性或逻辑回归分析主动脉 PWV 与结果参数之间的关联，协变量定义为年龄、性别、平均动脉压、心率、BMI、吸烟、糖尿病持续时间和高血压。平均主动脉 PWV 为 7.1±2.5 m/s。主动脉 PWV 与左心室射血分数 (ß = -0.406, P = 0.006)、左心室每搏输出量 (ß = -0.407, P = 0.001)、左心室心输出量 (ß = -0.458, P = 0.001) 和与脑 WMH（P < 0.05）。主动脉僵硬度与左心室质量、脑微出血或腔隙性梗死之间没有独立关联。主动脉僵硬度与 1 型糖尿病患者的左心室收缩功能和脑部 WMH 独立相关。
To evaluate, with the use of magnetic resonance imaging (MRI), whether aortic pulse wave velocity (PWV) is associated with cardiac left ventricular (LV) function and mass as well as with cerebral small vessel disease in patients with type 1 diabetes mellitus (DM). We included 86 consecutive type 1 DM patients (49 male, mean age 46.9 ± 11.7 years) in a prospective, cross-sectional study. Exclusion criteria included aortic/heart disease and general MRI contra-indications. MRI of the aorta, heart and brain was performed for assessment of aortic PWV, as a marker of aortic stiffness, systolic LV function and mass, as well as for the presence of cerebral white matter hyperintensities (WMHs), microbleeds and lacunar infarcts. Multivariate linear or logistic regression was performed to analyse the association between aortic PWV and outcome parameters, with covariates defined as age, gender, mean arterial pressure, heart rate, BMI, smoking, DM duration and hypertension. Mean aortic PWV was 7.1 ± 2.5 m/s. Aortic PWV was independently associated with LV ejection fraction (ß = -0.406, P = 0.006), LV stroke volume (ß = -0.407, P = 0.001), LV cardiac output (ß = -0.458, P = 0.001), and with cerebral WMHs (P < 0.05). There were no independent associations between aortic stiffness and LV mass, cerebral microbleeds or lacunar infarcts. Aortic stiffness is independently associated with systolic LV function and cerebral WMHs in patients with type 1 DM.
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影响因子：
1.3
作者：
Lamb, HJ;Doornbos, J;deRoos, A
通讯作者：
deRoos, A
影响因子：
12.3
作者：
Lastella, M
通讯作者：
Lastella, M
影响因子：
8.2
作者：
OXLUND, H;RASMUSSEN, LM;HEICKENDORFF, L
通讯作者：
HEICKENDORFF, L
影响因子：
4.4
作者：
Grotenhuis, Heynric B.;Westenberg, Jos M.;de Roos, Albert
通讯作者：
de Roos, Albert
影响因子：
5.4
作者：
Ohmine, Takahiro;Miwa, Yoshikazu;Sasaguri, Toshiyuki
通讯作者：
Sasaguri, Toshiyuki