Anti-diabetic effects of Bifidobacterium animalis 01 through improving hepatic insulin sensitivity in type 2 diabetic rat model
Anti-diabetic effects of Bifidobacterium animalis 01 through improving hepatic insulin sensitivity in type 2 diabetic rat model
复制标题
动物双歧杆菌 01 通过改善 2 型糖尿病大鼠模型肝脏胰岛素敏感性的抗糖尿病作用
DOI：
10.1016/j.jff.2020.103843
复制
发表时间：
2020-04
影响因子：
5.6
通讯作者：
Li Pinglan
中科院分区：
文献类型：
--
作者：
Zhang Jinlan;Wang Shibo;Zeng Zhu;Qin Yuxuan;Shen Qian;Li Pinglan
研究动物双歧杆菌01的抗糖尿病作用及其可能的作用机制。雄性SD大鼠给予高脂饲料和低剂量链脲佐菌素（30 mg/kg BW）诱导T2 DM。补充B.动物01以治疗前和治疗后方法给予。口服B. animalis 01降低食物和水的摄入量、血糖浓度和糖化血红蛋白水平。B.治疗animalis 01改善血清中的OGTT、HOMA-IR、脂质谱、代表性细胞因子和肝损伤标志物。animalis 01还通过减少肝组织损伤、增加糖原水平和改善抗氧化指数而表现出肝保护作用。此外，B. animalis 01处理对肝脏葡萄糖代谢和IRS/PI 3 K/AKT途径的基因表达产生了有益的影响。而且，B。animalis 01给药正调节肝Keap 1/Nrf 2途径。结果提示，B. animalis 01抗糖尿病的作用归因于IRS/PI 3 K/AKT和Keap 1/Nrf 2信号通路的激活。
The anti-diabetic effects ofBifidobacterium animalis01 and its potential mechanisms were investigated. Male SD rats were given a high-fat chow diet with low-dose streptozotocin (30 mg/kg BW) to induce T2DM. The supplements withB. animalis01 were given in a pre- and post-treatment method. Oral administration ofB. animalis01 decreased food and water intake, blood glucose concentration, and glycosylated hemoglobin level. Treatment withB. animalis01 improved OGTT, HOMA-IR, lipid profiles, representative cytokines, and liver injury markers in the serum.B. animalis01 also exhibited hepatoprotective effects by reducing hepatic tissues injuries, increasing the glycogen levels, and improving the antioxidant indexes. Furthermore,B. animalis01 treatment showed beneficial influence on the gene expressions of hepatic glucose metabolism and IRS/PI3K/AKT pathway. Moreover,B. animalis01 administration positively regulated hepatic Keap1/Nrf2 pathway. The results suggested that the hepatic protective effect ofB. animalis01 against diabetes attributed to IRS/PI3K/AKT and Keap1/Nrf2 signaling activation.
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影响因子：
29
作者：
Lin HV;Accili D
通讯作者：
Accili D
DOI：
10.1016/j.biopha.2018.06.108
发表时间：
2018-09
期刊：
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
影响因子：
--
作者：
Min Yang;Zhenhuan Jiang;Chenguang Li;Yanjuan Zhu;Zhu Li;Yunzhao Tang;C. Ni
通讯作者：
Min Yang;Zhenhuan Jiang;Chenguang Li;Yanjuan Zhu;Zhu Li;Yunzhao Tang;C. Ni
鼠李糖乳杆菌 hsryfm 1301 对高脂血症大鼠模型肠道菌群的影响
影响因子：
--
作者：
Chen D;Yang Z;Chen X;Huang Y;Yin B;Guo F;Zhao H;Zhao T;Qu H;Huang J;Wu Y;Gu R
通讯作者：
Gu R
影响因子：
3.6
作者：
Andreasen, Anne Sofie;Larsen, Nadja;Pedersen, Bente Klarlund
通讯作者：
Pedersen, Bente Klarlund
影响因子：
7.7
作者：
Morino, Katsutaro;Petersen, Kitt Falk;Shulman, Gerald I.
通讯作者：
Shulman, Gerald I.