The effect of soy isoflavones on arterial stiffness: a systematic review and meta-analysis of randomized controlled trials.
The effect of soy isoflavones on arterial stiffness: a systematic review and meta-analysis of randomized controlled trials.
复制标题
大豆异黄酮对动脉硬化的影响：随机对照试验的系统综述和荟萃分析。
DOI：
10.1007/s00394-020-02300-6
复制
发表时间：
2021-03
影响因子：
5
通讯作者：
Sekikawa A
中科院分区：
文献类型：
--
作者：
Man B;Cui C;Zhang X;Sugiyama D;Barinas-Mitchell E;Sekikawa A
一些但不是所有的大豆异黄酮的随机对照试验（RCT）显示了它们对动脉硬化的有益作用，这是心血管事件，痴呆和全因死亡率的预测因子，独立于传统的风险因素。为了验证补充大豆异黄酮可以降低动脉僵硬度的假设，我们对大豆异黄酮治疗动脉僵硬度的随机对照试验进行了系统回顾和荟萃分析。本系统性综述的方案已在PROSPERO注册（CRD 42019126128），并按照PRISMA编写。使用以下标准检索PubMed、Embase和clinicaltrials.gov数据库：人类受试者，大豆异黄酮作为干预，动脉僵硬度作为主要结局。随机效应荟萃分析用于汇总研究间的估计值。标准化平均差（SMD）用于合成定量结果。在检索到的998篇文章中，8篇符合我们的标准。干预持续时间相对较短（最长12周）。结果测量提取脉搏波速度（PWV），体动脉顺应性（SAC），增强指数（AI），和心踝血管指数（CAVI）。与安慰剂相比，大豆异黄酮降低了动脉硬度（标准化平均差异：-0.33，95%置信区间：-0.47，-0.19）。亚组分析显示，干预持续时间（<6周vs. ≥ 6周）或性别（仅女性vs.仅男性vs.合并）的治疗效果无差异。敏感性分析表明，在PWV，CAVI，SAC和AI之间的大豆异黄酮的效果没有差异。补充大豆异黄酮可降低动脉僵硬度。需要更长时间的试验和更多的参与者。
Some but not all randomized controlled trials (RCTs) of soy isoflavones showed their beneficial effect on arterial stiffness, a predictor of cardiovascular events, dementia, and all-cause mortality, independent of traditional risk factors. To test the hypothesis that supplementation of soy isoflavones reduces arterial stiffness, we performed a systematic review and meta-analysis of RCTs of soy isoflavones on arterial stiffness. The protocol of this systematic review was registered with PROSPERO (CRD42019126128) and written in accordance with PRISMA. The PubMed, Embase, and clinicaltrials.gov databases were searched using the following criteria: human subjects, soy isoflavones as intervention, and arterial stiffness as primary outcome. A random-effects meta-analysis was used to pool estimates across studies. Standardized mean difference (SMD) was used to synthesize quantitative results. Among 998 articles retrieved, 8 articles met our criteria. Duration of intervention was relatively short (maximum of 12 weeks). Outcome measurements extracted were pulse wave velocity (PWV), systemic arterial compliance (SAC), augmentation index (AI), and cardio-ankle vascular index (CAVI). Soy isoflavones reduced arterial stiffness compared to placebo (Standardized Mean Difference: −0.33, 95% confidence interval: −0.47, −0.19). Subgroup analyses showed no difference between treatment effects for intervention duration (<6weeks vs. ≥6weeks) or gender (women only vs. men only vs. combined). Sensitivity analysis showed no difference in the effect of soy isoflavones between PWV, CAVI, SAC, and AI. Supplementation of soy isoflavones reduced arterial stiffness. Longer-duration trials with larger number of participants are warranted.
登录
查看更多内容
DOI：
10.1097/gme.0b013e3181857979
发表时间：
2009-03
期刊：
Menopause (New York, N.Y.)
影响因子：
--
作者：
Charles C;Yuskavage J;Carlson O;John M;Tagalicud AS;Maggio M;Muller DC;Egan J;Basaria S
通讯作者：
Basaria S
影响因子：
5.9
作者：
Messina M
通讯作者：
Messina M
影响因子：
2
作者：
Morito, K;Aomori, T;Masamune, Y
通讯作者：
Masamune, Y
DOI：
10.1017/s000711451700143x
发表时间：
2017-05
期刊：
The British journal of nutrition
影响因子：
--
作者：
Richter CK;Skulas-Ray AC;Fleming JA;Link CJ;Mukherjea R;Krul ES;Kris-Etherton PM
通讯作者：
Kris-Etherton PM
DOI：
10.3945/ajcn.115.125690
发表时间：
2016-03
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Hazim S;Curtis PJ;Schär MY;Ostertag LM;Kay CD;Minihane AM;Cassidy A
通讯作者：
Cassidy A