MRI-assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction.
MRI-assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction.
复制标题
MRI评估的蓝斑完整性是可遗传的，并与多个认知域、轻度认知障碍和日间功能障碍相关。
DOI：
10.1002/alz.12261
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Kremen WS
中科院分区：
文献类型：
--
作者：
Elman JA;Puckett OK;Beck A;Fennema-Notestine C;Cross LK;Dale AM;Eglit GML;Eyler LT;Gillespie NA;Granholm EL;Gustavson DE;Hagler DJ Jr;Hatton SN;Hauger R;Jak AJ;Logue MW;McEvoy LK;McKenzie RE;Neale MC;Panizzon MS;Reynolds CA;Sanderson-Cimino M;Toomey R;Tu XM;Whitsel N;Williams ME;Xian H;Lyons MJ;Franz CE;Kremen WS
阿尔茨海默病（AD）早期蓝斑（LC）发生广泛的神经退行性变。LC参与调节睡眠-觉醒周期，调节认知功能和AD进展。参与者是481名来自越南时代老龄化双胞胎研究的男性（年龄62至71.7岁）。LC结构完整性通过神经黑色素敏感磁共振成像（MRI）对比噪声比（LCCNR）来衡量。我们检查了LCCNR、认知、遗忘型轻度认知功能障碍（aMCI）和日间功能障碍。LCCNR的遗传力为0.48。患有aMCI的参与者表现出更大的日间功能障碍。较低的LCCNR与较差的情景记忆、一般语言流畅性、语义流畅性和处理速度相关，以及aMCI和更大的日间功能障碍的几率增加。LC完整性降低与认知领域的广泛差异、日间睡眠相关功能障碍和aMCI风险相关。这些在中晚期成年人中的发现强调了基于MRI的LC完整性测量在早期识别AD风险中的潜力。
The locus coeruleus (LC) undergoes extensive neurodegeneration in early Alzheimer's disease (AD). The LC is implicated in regulating the sleep–wake cycle, modulating cognitive function, and AD progression. Participants were 481 men (ages 62 to 71.7) from the Vietnam Era Twin Study of Aging. LC structural integrity was indexed by neuromelanin‐sensitive magnetic resonance imaging (MRI) contrast‐to‐noise ratio (LCCNR). We examined LCCNR, cognition, amnestic mild cognitive impairment (aMCI), and daytime dysfunction. Heritability of LCCNR was .48. Participants with aMCI showed greater daytime dysfunction. Lower LCCNR was associated with poorer episodic memory, general verbal fluency, semantic fluency, and processing speed, as well as increased odds of aMCI and greater daytime dysfunction. Reduced LC integrity is associated with widespread differences across cognitive domains, daytime sleep‐related dysfunction, and risk for aMCI. These findings in late‐middle‐aged adults highlight the potential of MRI‐based measures of LC integrity in early identification of AD risk.
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DOI：
10.1126/science.1180962
发表时间：
2009-11-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kang JE;Lim MM;Bateman RJ;Lee JJ;Smyth LP;Cirrito JR;Fujiki N;Nishino S;Holtzman DM
通讯作者：
Holtzman DM
影响因子：
4.2
作者：
Kalinin, Sergey;Gavrilyuk, Vitaliy;Feinstein, Douglas L.
通讯作者：
Feinstein, Douglas L.
影响因子：
2.6
作者：
Gustavson DE;Panizzon MS;Elman JA;Franz CE;Beck A;Reynolds CA;Jacobson KC;Xian H;Toomey R;Lyons MJ;Kremen WS
通讯作者：
Kremen WS
DOI：
10.1073/pnas.1712268115
发表时间：
2018-02-27
影响因子：
11.1
作者：
Hämmerer D;Callaghan MF;Hopkins A;Kosciessa J;Betts M;Cardenas-Blanco A;Kanowski M;Weiskopf N;Dayan P;Dolan RJ;Düzel E
通讯作者：
Düzel E
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y