Genetic and Environmental Influences on Verbal Fluency in Middle Age: A Longitudinal Twin Study.
Genetic and Environmental Influences on Verbal Fluency in Middle Age: A Longitudinal Twin Study.
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DOI：
10.1007/s10519-018-9910-6
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发表时间：
2018-09
影响因子：
2.6
通讯作者：
Kremen WS
中科院分区：
文献类型：
--
作者：
Gustavson DE;Panizzon MS;Elman JA;Franz CE;Beck A;Reynolds CA;Jacobson KC;Xian H;Toomey R;Lyons MJ;Kremen WS
越来越多的证据表明，音素流畅性和语义流畅性的措施与其他认知和健康表型差异相关，但很少有研究探讨其共享和独特的方差，特别是使用遗传信息设计。在这项研究中，1464名中年双胞胎在两个时间点（平均年龄56岁和62岁）完成了六项流畅性子测试。解释性因素分析支持一个两因素的解决方案：一般流畅性的潜在因素解释的变化，在所有六个子测试和语义特定的因素占语义子测试的额外的方差。这两个因素主要是由遗传影响在两个波（a2= 0.57至0.76）。在六年的时间里，个体差异具有相当大的稳定性（通用流利性的r= 0.90，语义特异性的r= 0.81），特别是遗传影响（rg= 0.94和1.0，分别）。这些结果表明，语义流畅性可以被看作是一个组合的一般和语义特定的变化，但音素流畅性是完全捕获的一般因素。
Mounting evidence suggests that measures of phonemic fluency and semantic fluency are differentially associated with other cognitive and health phenotypes, but few studies have examined their shared and unique variance, especially using genetically-informative designs. In this study, 1464 middle-aged twins completed six fluency subtests at up to two time-points (mean age 56 and 62 years). Confirmatory factor analyses supported a two-factor solution: a General Fluency latent factor explained variation in all six subtests and a Semantic-Specific factor accounted for additional variance in semantic subtests. Both factors were explained primarily by genetic influences at both waves (a2=.57 to .76). There was considerable stability of individual differences over six years (r=.90 for General Fluency, r=.81 for Semantic-Specific), especially for genetic influences (rg=.94 and 1.0, respectively). These results suggest that semantic fluency can be viewed as a combination of general and semantic-specific variance, but phonemic fluency is captured entirely by the general factor.
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影响因子：
3
作者：
Boker S;Neale M;Maes H;Wilde M;Spiegel M;Brick T;Spies J;Estabrook R;Kenny S;Bates T;Mehta P;Fox J
通讯作者：
Fox J
影响因子：
1.7
作者：
Henry, Julie D;Crawford, John R
通讯作者：
Crawford, John R
影响因子：
0.9
作者：
Kremen, William S.;Thompson-Brenner, Heather;Lyons, Michael J.
通讯作者：
Lyons, Michael J.
影响因子：
6.7
作者：
Giubilei, Franco;Medda, Emanuela;Stazi, Maria A.
通讯作者：
Stazi, Maria A.
DOI：
10.1016/j.dadm.2018.04.003
发表时间：
2018
期刊：
Alzheimer's & dementia (Amsterdam, Netherlands)
影响因子：
--
作者：
Elman JA;Jak AJ;Panizzon MS;Tu XM;Chen T;Reynolds CA;Gustavson DE;Franz CE;Hatton SN;Jacobson KC;Toomey R;McKenzie R;Xian H;Lyons MJ;Kremen WS
通讯作者：
Kremen WS