POSTAR2: deciphering the post-transcriptional regulatory logics.

POSTAR2: deciphering the post-transcriptional regulatory logics.
复制标题

POSTAR2:破译转录后调控逻辑

DOI:
10.1093/nar/gky830
复制
发表时间:
2019-01-08
影响因子:
14.9
通讯作者:
Wang P
Wang P
中科院分区:
生物学2区
文献类型:
--
作者:
Zhu Y;Xu G;Yang YT;Xu Z;Chen X;Shi B;Xie D;Lu ZJ;Wang P

文献摘要

参考文献

被引文献

相似文献

rna的转录后调控对多种细胞过程至关重要。近年来,专注于转录后调控逻辑的功能基因组数据量持续增长。在当前的数据库版本POSTAR2 (http://lulab.life.tsinghua.edu.cn/postar)中,我们纳入了以下新特征和数据:更新了来自6个物种的约500个CLIP-seq数据集(总共约1200个CLIP-seq数据集),包括人类、小鼠、苍蝇、蠕虫、拟南芥和酵母;增加了一个新的模块“Translatome”,该模块来自Ribo-seq数据集,包含来自六个物种的基因组中的约3600万个开放阅读框(orf);更新和统一的转录后调控和变异数据。最后,我们利用多层信息改进了搜索和可视化蛋白质- rna相互作用的web界面。同时,我们还将CLIPdb数据库合并到POSTAR2中。POSTAR2将帮助研究人员研究rna结合蛋白和细胞rna翻译景观协调的转录后调控逻辑。
Abstract Post-transcriptional regulation of RNAs is critical to the diverse range of cellular processes. The volume of functional genomic data focusing on post-transcriptional regulation logics continues to grow in recent years. In the current database version, POSTAR2 (http://lulab.life.tsinghua.edu.cn/postar), we included the following new features and data: updated ∼500 CLIP-seq datasets (∼1200 CLIP-seq datasets in total) from six species, including human, mouse, fly, worm, Arabidopsis and yeast; added a new module ‘Translatome’, which is derived from Ribo-seq datasets and contains ∼36 million open reading frames (ORFs) in the genomes from the six species; updated and unified post-transcriptional regulation and variation data. Finally, we improved web interfaces for searching and visualizing protein–RNA interactions with multi-layer information. Meanwhile, we also merged our CLIPdb database into POSTAR2. POSTAR2 will help researchers investigate the post-transcriptional regulatory logics coordinated by RNA-binding proteins and translational landscape of cellular RNAs.
DOI: 10.1093/bioinformatics/btr064
发表时间: 2011-04-01
期刊: Bioinformatics (Oxford, England)
影响因子: --
作者:
Grant CE;Bailey TL;Noble WS
通讯作者: Noble WS
starBase v2.0:从大规模 CLIP-Seq 数据中解码 miRNA-ceRNA、miRNA-ncRNA 和蛋白质-RNA 相互作用网络
DOI: 10.1093/nar/gkt1248
发表时间: 2014-01
影响因子: 14.9
作者:
Li JH;Liu S;Zhou H;Qu LH;Yang JH
通讯作者: Yang JH
DOI: 10.1101/gr.135350.111
发表时间: 2012-09
期刊: Genome research
影响因子: 7
作者:
Harrow J;Frankish A;Gonzalez JM;Tapanari E;Diekhans M;Kokocinski F;Aken BL;Barrell D;Zadissa A;Searle S;Barnes I;Bignell A;Boychenko V;Hunt T;Kay M;Mukherjee G;Rajan J;Despacio-Reyes G;Saunders G;Steward C;Harte R;Lin M;Howald C;Tanzer A;Derrien T;Chrast J;Walters N;Balasubramanian S;Pei B;Tress M;Rodriguez JM;Ezkurdia I;van Baren J;Brent M;Haussler D;Kellis M;Valencia A;Reymond A;Gerstein M;Guigó R;Hubbard TJ
通讯作者: Hubbard TJ
DOI: 10.1002/wrna.1465
发表时间: 2018-05
期刊: Wiley interdisciplinary reviews. RNA
影响因子: --
作者:
Harvey RF;Smith TS;Mulroney T;Queiroz RML;Pizzinga M;Dezi V;Villenueva E;Ramakrishna M;Lilley KS;Willis AE
通讯作者: Willis AE
DOI: 10.1016/j.molcel.2010.05.004
发表时间: 2010-05-28
期刊: Molecular cell
影响因子: 16
作者:
Heinz S;Benner C;Spann N;Bertolino E;Lin YC;Laslo P;Cheng JX;Murre C;Singh H;Glass CK
通讯作者: Glass CK