Trans-acting translational regulatory RNA binding proteins.
Trans-acting translational regulatory RNA binding proteins.
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DOI：
10.1002/wrna.1465
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Willis AE
中科院分区：
文献类型：
--
作者：
Harvey RF;Smith TS;Mulroney T;Queiroz RML;Pizzinga M;Dezi V;Villenueva E;Ramakrishna M;Lilley KS;Willis AE
全球mRNA翻译及其控制所需的典型分子机制已经得到很好的定义，其中不同的蛋白质组参与翻译起始，延伸和终止的过程。此外，非经典的反式作用调节RNA结合蛋白（RBP）是提供mRNA特异性翻译所必需的，它们与mRNA的5′和3′非翻译区和编码区相互作用，以调节核糖体的募集和转运。最近也有研究表明，反式作用核糖体蛋白指导特定mRNA的翻译。重要的是，已经表明RBP的子集通常协同工作，在不同的细胞扰动下形成不同的调控复合物，产生RBP组合密码，其通过特定mRNA子集的翻译决定细胞命运。随着新方法的发展，最近已经鉴定了大量新的RNA结合蛋白，尽管许多这些蛋白在mRNA翻译中的功能是未知的。在这篇综述中，我们将讨论这些方法及其应用于翻译研究时的缺点，需要解决这些问题，以便更好地了解反式作用的翻译调控蛋白。此外，我们讨论了负责RNA结合的蛋白质结构域以及它们结合的RNA基序，以及反式作用核糖体蛋白在指导特定mRNA翻译中的作用。RNA与蛋白质和其他分子的相互作用> RNA-蛋白质复合物翻译>翻译调节翻译>翻译机制这篇文章分类下：
The canonical molecular machinery required for global mRNA translation and its control has been well defined, with distinct sets of proteins involved in the processes of translation initiation, elongation and termination. Additionally, noncanonical, trans‐acting regulatory RNA‐binding proteins (RBPs) are necessary to provide mRNA‐specific translation, and these interact with 5′ and 3′ untranslated regions and coding regions of mRNA to regulate ribosome recruitment and transit. Recently it has also been demonstrated that trans‐acting ribosomal proteins direct the translation of specific mRNAs. Importantly, it has been shown that subsets of RBPs often work in concert, forming distinct regulatory complexes upon different cellular perturbation, creating an RBP combinatorial code, which through the translation of specific subsets of mRNAs, dictate cell fate. With the development of new methodologies, a plethora of novel RNA binding proteins have recently been identified, although the function of many of these proteins within mRNA translation is unknown. In this review we will discuss these methodologies and their shortcomings when applied to the study of translation, which need to be addressed to enable a better understanding of trans‐acting translational regulatory proteins. Moreover, we discuss the protein domains that are responsible for RNA binding as well as the RNA motifs to which they bind, and the role of trans‐acting ribosomal proteins in directing the translation of specific mRNAs. RNA Interactions with Proteins and Other Molecules > RNA–Protein Complexes Translation > Translation Regulation Translation > Translation Mechanisms This article is categorized under:
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DOI：
10.1016/j.cub.2017.01.047
发表时间：
2017-03-06
期刊：
Current biology : CB
影响因子：
--
作者：
Bastide A;Peretti D;Knight JR;Grosso S;Spriggs RV;Pichon X;Sbarrato T;Roobol A;Roobol J;Vito D;Bushell M;von der Haar T;Smales CM;Mallucci GR;Willis AE
通讯作者：
Willis AE
影响因子：
13.6
作者：
Chang SH;Hla T
通讯作者：
Hla T
影响因子：
16.6
作者：
Beckmann BM;Horos R;Fischer B;Castello A;Eichelbaum K;Alleaume AM;Schwarzl T;Curk T;Foehr S;Huber W;Krijgsveld J;Hentze MW
通讯作者：
Hentze MW
影响因子：
5.3
作者：
AVNI, D;SHAMA, S;MEYUHAS, O
通讯作者：
MEYUHAS, O
影响因子：
14.8
作者：
Castello, Alfredo;Horos, Rastislav;Hentze, Matthias W.
通讯作者：
Hentze, Matthias W.