Development of a common scale for measuring healthy ageing across the world: results from the ATHLOS consortium.

Development of a common scale for measuring healthy ageing across the world: results from the ATHLOS consortium.
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DOI:
10.1093/ije/dyaa236
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发表时间:
2021-07-09
影响因子:
7.7
通讯作者:
ATHLOS Consortium
ATHLOS Consortium
中科院分区:
医学1区
文献类型:
--
作者:
Sanchez-Niubo A;Forero CG;Wu YT;Giné-Vázquez I;Prina M;De La Fuente J;Daskalopoulou C;Critselis E;De La Torre-Luque A;Panagiotakos D;Arndt H;Ayuso-Mateos JL;Bayes-Marin I;Bickenbach J;Bobak M;Caballero FF;Chatterji S;Egea-Cortés L;García-Esquinas E;Leonardi M;Koskinen S;Koupil I;Mellor-Marsá B;Olaya B;Pająk A;Prince M;Raggi A;Rodríguez-Artalejo F;Sanderson W;Scherbov S;Tamosiunas A;Tobias-Adamczyk B;Tyrovolas S;Haro JM;ATHLOS Consortium

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衡量健康老龄化概念的研究工作多种多样,仅限于特定人群。这种多样性限制了比较不同国家和/或人口的健康老龄化的可能性。在这项研究中,我们开发了一个新的测量规模的健康老龄化使用全球队列。在老龄化健康轨迹-纵向机会和协同作用项目中,统一了来自16个国际群组的数据。使用ATHLOS数据,项目反应理论(IRT)模型被用来开发一个规模与健康和功能相关的41个项目。测量异质性,由于数据集内的特异性进行检测,通过逻辑回归框架应用差异项功能。该模型通过引入队列特异性参数(使用等同程序将评分重新调整至主量表)来解释模型参数的特异性。对所有个体的最终评分进行估计,并转换为T评分,平均值为50,标准差为10。为来自16项研究的343915名18岁以上的个体创建了一个通用量表。该量表显示了关于各种社会人口学、生活和健康因素的并行有效性的可靠证据,以及与健康预期寿命(r = 0.81)和国内生产总值(r = 0.58)的收敛有效性。生存曲线表明,该量表也可以预测死亡率。ATHLOS量表由于其可靠性和全球代表性,有可能促进世界范围的健康老龄化研究。
Research efforts to measure the concept of healthy ageing have been diverse and limited to specific populations. This diversity limits the potential to compare healthy ageing across countries and/or populations. In this study, we developed a novel measurement scale of healthy ageing using worldwide cohorts. In the Ageing Trajectories of Health-Longitudinal Opportunities and Synergies (ATHLOS) project, data from 16 international cohorts were harmonized. Using ATHLOS data, an item response theory (IRT) model was used to develop a scale with 41 items related to health and functioning. Measurement heterogeneity due to intra-dataset specificities was detected, applying differential item functioning via a logistic regression framework. The model accounted for specificities in model parameters by introducing cohort-specific parameters that rescaled scores to the main scale, using an equating procedure. Final scores were estimated for all individuals and converted to T-scores with a mean of 50 and a standard deviation of 10. A common scale was created for 343 915 individuals above 18 years of age from 16 studies. The scale showed solid evidence of concurrent validity regarding various sociodemographic, life and health factors, and convergent validity with healthy life expectancy (r = 0.81) and gross domestic product (r = 0.58). Survival curves showed that the scale could also be predictive of mortality. The ATHLOS scale, due to its reliability and global representativeness, has the potential to contribute to worldwide research on healthy ageing.
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