Human papillomavirus in head and neck cancer.

Human papillomavirus in head and neck cancer.
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DOI:
10.3390/cancers6031705
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发表时间:
2014-08-18
期刊:
影响因子:
5.2
通讯作者:
Garbuglia AR
Garbuglia AR
中科院分区:
医学2区
文献类型:
--
作者:
Garbuglia AR

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人类乳头瘤病毒(HPV)目前被认为是除烟草和酒精外,口咽癌(OPC)发生的主要病因。HPV阳性OPC具有不同于HPV阴性OPC的流行病学特征,具有发病年龄小、以男性为主、与性行为密切相关等特点。HPV16型是口腔癌中最常见的HPV型,且口腔中β、伽玛型HPV型的患病率高于甲型HPV型。
Human papillomavirus (HPV) is currently considered to be a major etiologic factor, in addition to tobacco and alcohol, for oropharyngeal cancer (OPC) development. HPV positive OPCs are epidemiologically distinct from HPV negative ones, and are characterized by younger age at onset, male predominance, and strong association with sexual behaviors. HPV16 is the most prevalent types in oral cavity cancer (OCC), moreover the prevalence of beta, and gamma HPV types is higher than that of alpha HPV in oral cavity.
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