Strong associations of telomere length and mitochondrial copy number with suicidality and abuse history in adolescent depressed individuals.
Strong associations of telomere length and mitochondrial copy number with suicidality and abuse history in adolescent depressed individuals.
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DOI：
10.1038/s41380-023-02263-0
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发表时间：
2023-09
影响因子：
11
通讯作者：
Dwivedi, Yogesh
中科院分区：
文献类型：
--
作者：
Ochi, Shinichiro;Roy, Bhaskar;Prall, Kevin;Shelton, Richard C.;Dwivedi, Yogesh
重度抑郁症（MDD）在青少年中非常普遍，是自杀的主要危险因素。最近的证据表明，在成人中，细胞加速衰老与包括抑郁症在内的精神疾病有关。本研究调查了端粒长度（TL）和线粒体DNA拷贝数（mtDNAcn）这两个细胞衰老的关键指标在抑郁症青少年中是否发生改变，以及这些改变是否与自杀、早期生活逆境和其他共同发生的因素有关。对53例青少年（16-19岁，19例有自杀企图/自杀意念的MDD [MDD + SI/SA]， 14例无SA/SI的MDD [MDD-SI/SA]， 20例健康对照[HC]）的基因组DNA进行TL和mtDNAcn的测定，以端粒重复数与单拷贝核血红蛋白[HBG]基因重复数之比或mtDNA （NADH脱氢酶，亚基1）相对于HBG的数量。我们的数据显示，总MDD组的TL显著低于HC， mtDNAcn显著高于HC。MDD + SA/SI组TL显著低于HC组，mtDNAcn显著高于HC组，而MDD-SI/SA组差异无统计学意义。HC组和MDD-SA/SI组TL与mtDNAcn呈正相关；而MDD + SA/SI患者TL与mtDNAcn呈负相关。TL与抑郁、焦虑严重程度呈负相关，mtDNAcn与既往情绪虐待严重程度呈正相关。我们的研究表明，在有自杀意念的抑郁青少年中，细胞衰老更为严重，儿童时期的情绪虐待可能参与了这一过程。
Major depressive disorder (MDD) is highly prevalent in adolescents and is a major risk factor for suicidality. Recent evidence shows that accelerated cellular senescence/aging is associated with psychiatric illness, including depression, in adults. The present study examined if the relationships of telomere length (TL) and mitochondrial DNA copy number (mtDNAcn), two critical indicators of cellular senescence/aging, are altered in depressed adolescents and whether these alterations are associated with suicidality, early-life adversities, and other co-occuring factors. In genomic DNA isolated from 53 adolescents (ages 16–19, 19 MDD with suicide attempt/suicidal ideation [MDD + SI/SA], 14 MDD without SA/SI [MDD-SI/SA], and 20 healthy controls [HC]), TL and mtDNAcn were measured as the ratio between the number of telomere repeats and that of a single-copy nuclear-hemoglobin [HBG] gene or the amount of mtDNA (NADH dehydrogenase, subunit 1) relative to HBG. Our data show that TL was significantly lower, and mtDNAcn was significantly higher in the total MDD group than HC. TL was significantly lower and mtDNAcn was significantly higher in the MDD + SA/SI group than in the HC, whereas there were no differences in the MDD-SI/SA group. TL was positively correlated with mtDNAcn in both HC and MDD-SA/SI groups; however, TL was negatively correlated with mtDNAcn in MDD + SA/SI. Furthermore, TL was negatively correlated with the severity of both depression and anxiety, while mtDNAcn was positively correlated with the severity of prior emotional abuse. Our study indicates that cellular senescence is more advanced in depressed adolescents with suicidal ideation and that childhood emotional abuse may participate in such a process.
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DOI：
10.1016/j.cub.2015.10.065
发表时间：
2015-12-21
期刊：
Current biology : CB
影响因子：
--
作者：
Cai N;Li Y;Chang S;Liang J;Lin C;Zhang X;Liang L;Hu J;Chan W;Kendler KS;Malinauskas T;Huang GJ;Li Q;Mott R;Flint J
通讯作者：
Flint J
DOI：
10.15252/embj.201592862
发表时间：
2016-04-01
期刊：
The EMBO journal
影响因子：
--
作者：
Correia-Melo C;Marques FD;Anderson R;Hewitt G;Hewitt R;Cole J;Carroll BM;Miwa S;Birch J;Merz A;Rushton MD;Charles M;Jurk D;Tait SW;Czapiewski R;Greaves L;Nelson G;Bohlooly-Y M;Rodriguez-Cuenca S;Vidal-Puig A;Mann D;Saretzki G;Quarato G;Green DR;Adams PD;von Zglinicki T;Korolchuk VI;Passos JF
通讯作者：
Passos JF
影响因子：
6.6
作者：
Birkenaes, Viktoria;Elvsashagen, Torbjorn;Aas, Monica
通讯作者：
Aas, Monica
影响因子：
17.7
作者：
Dwyer, Jennifer B.;Landeros-Weisenberger, Angeli;Bloch, Michael H.
通讯作者：
Bloch, Michael H.
影响因子：
15.1
作者：
Choi, Jenny;Fauce, Steven R.;Effros, Rita B.
通讯作者：
Effros, Rita B.