Regional increases of cortical thickness in untreated, first-episode major depressive disorder.
Regional increases of cortical thickness in untreated, first-episode major depressive disorder.
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未经治疗的首发重度抑郁症患者皮质厚度的区域性增加
DOI：
10.1038/tp.2014.18
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发表时间：
2014-04-08
影响因子：
6.8
通讯作者：
Gong Q
中科院分区：
文献类型：
--
作者：
Qiu L;Lui S;Kuang W;Huang X;Li J;Li J;Zhang J;Chen H;Sweeney JA;Gong Q
大多数主要抑郁障碍(MDD)的结构MRI研究调查了慢性药物治疗患者的体积变化，在这些患者中，病程和治疗效果可能会影响解剖测量。此外，在少数研究中，已经进行了皮质厚度和表面积的单独测量，以反映受不同遗传机制调控的不同神经生物学过程。在这项研究中，我们研究了首发、治疗幼稚的中年MDD的皮质厚度和表面积，以阐明这种疾病的核心病理生理学及其对大脑的早期影响。我们观察到右侧大脑半球皮质厚度增加，包括眶前内侧回、盖部、吻侧额中回和缘上回。在汉密尔顿抑郁量表上，额中回吻侧厚度的增加与抑郁程度呈负相关。此外，MDD患者在观察到皮质厚度增加的区域之间的皮质厚度测量显示显著增加的相关性。软膜面积分析显示，MDD患者左侧海马旁回的表面积有增加的趋势。为了能够将我们的数据与以前的灰质体积研究的数据进行比较，我们进行了基于体素的形态测量。分析显示，左侧中央旁小叶、左侧额上回、双侧楔脑和丘脑的灰质体积显著增加，形成边缘-皮质-纹状-苍白-丘脑环状结构。首发、未接受治疗的中年MDD患者的这些变化可能反映了临近发病时与疾病相关的活跃的皮质变化，因此可能为该疾病的早期神经生物学提供重要的新见解。
The large majority of structural MRI studies of major depressive disorder (MDD) investigated volumetric changes in chronic medicated patients in whom course of illness and treatment effects may impact anatomic measurements. Further, in few studies, separate measurements of cortical thickness and surface area have been performed that reflect different neurobiological processes regulated by different genetic mechanisms. In the present study, we investigated both cortical thickness and surface area in first-episode, treatment-naïve, mid-life MDD to elucidate the core pathophysiology of this disease and its early impact on the brain. We observed increased cortical thickness in the right hemisphere, including medial orbitofrontal gyrus, pars opercularis, rostral middle frontal gyrus and supramarginal gyrus. Increased thickness of rostral middle frontal gyrus was negatively related with depression severity on the Hamilton Depression Rating Scale. Furthermore, MDD patients showed significantly increased associations in cortical thickness measurements among areas where increased cortical thickness was observed. Analysis of pial area revealed a trend toward increased surface area in the left parahippocampal gyrus in MDD. To permit comparison of our data with those of previous gray matter volume studies, voxel-based morphometry was performed. That analysis revealed significantly increased gray matter volume in left paracentral lobule, left superior frontal gyrus, bilateral cuneus and thalamus which form limbic-cortico–striato–pallido–thalamic loops. These changes in first-episode, treatment-naïve, mid-life MDD patients may reflect an active illness-related cortical change close to illness onset, and thus potentially provide important new insight into the early neurobiology of the disorder.
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DOI：
10.1523/jneurosci.1929-08.2008
发表时间：
2008-09-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bassett DS;Bullmore E;Verchinski BA;Mattay VS;Weinberger DR;Meyer-Lindenberg A
通讯作者：
Meyer-Lindenberg A
影响因子：
6.6
作者：
Colloby, Sean J.;Firbank, Michael J.;O'Brien, John T.
通讯作者：
O'Brien, John T.
影响因子：
10.6
作者：
Dowlati, Yekta;Herrmann, Nathan;Lanctot, Krista L.
通讯作者：
Lanctot, Krista L.
影响因子：
5.3
作者：
Beauregard, M;Lévesque, J;Bourgouin, P
通讯作者：
Bourgouin, P
影响因子：
6.7
作者：
Jarnum, Hanna;Eskildsen, Simon F.;Larsson, Elna-Marie
通讯作者：
Larsson, Elna-Marie