Organic Field-Effect Transistors as Flexible, Tissue-Equivalent Radiation Dosimeters in Medical Applications.
Organic Field-Effect Transistors as Flexible, Tissue-Equivalent Radiation Dosimeters in Medical Applications.
复制标题
DOI：
10.1002/advs.202001522
复制
发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Jurchescu OD
中科院分区：
文献类型：
--
作者：
Zeidell AM;Ren T;Filston DS;Iqbal HF;Holland E;Bourland JD;Anthony JE;Jurchescu OD
放射治疗是癌症治疗中最普遍的方法之一，但是由周围射束在靶周围的健康组织中诱发恶性肿瘤的风险很高。因此，能够准确测量暴露剂量是患者护理的一个关键方面。这里介绍了一种基于有机场效应晶体管（RAD‐OFET）的辐射探测器，这是一种体内剂量计，可以直接放置在患者皮肤上，以真实的时间验证输送的剂量，并确保附近区域接收到可接受的低剂量水平。该设备减少了当前技术在近似患者体内剂量分布时所面临的误差，对与放射治疗程序相关的剂量敏感，并且在并入适形大面积电子器件时具有鲁棒性。提出了一个模型来描述RAD-OFFERS的操作，基于电荷光生和捕获之间的相互作用。介绍了一种基于有机场效应晶体管（RAD‐OFET）的辐射探测器，用于被动辐射剂量测定。RAD‐ OFFERT是组织等效器械，可直接放置在患者皮肤上，直接测量辐射剂量输送，对许多放射治疗程序相关的剂量敏感。
Radiation therapy is one of the most prevalent procedures for cancer treatment, but the risks of malignancies induced by peripheral beam in healthy tissues surrounding the target is high. Therefore, being able to accurately measure the exposure dose is a critical aspect of patient care. Here a radiation detector based on an organic field‐effect transistor (RAD‐OFET) is introduced, an in vivo dosimeter that can be placed directly on a patient's skin to validate in real time the dose being delivered and ensure that for nearby regions an acceptable level of low dose is being received. This device reduces the errors faced by current technologies in approximating the dose profile in a patient's body, is sensitive for doses relevant to radiation treatment procedures, and robust when incorporated into conformal large‐area electronics. A model is proposed to describe the operation of RAD‐OFETs, based on the interplay between charge photogeneration and trapping. A radiation detector based on an organic field‐effect transistor (RAD‐OFET) is introduced for passive radiation dosimetry. RAD‐OFETs are tissue‐equivalent devices that can be placed directly on a patient's skin to directly measure radiation dose delivery and are sensitive for doses relevant to many radiation treatment procedures.
登录
查看更多内容
影响因子：
29.4
作者：
Bansal, Ashu K.;Hou, Shuoben;Samuel, Ifor D. W.
通讯作者：
Samuel, Ifor D. W.
影响因子：
2
作者：
Hupman, Michael A.;Hill, Ian G.;Syme, Alasdair
通讯作者：
Syme, Alasdair
影响因子：
8.6
作者：
Podzorov, V;Menard, E;Gershenson, ME
通讯作者：
Gershenson, ME
影响因子：
3.2
作者：
Lamport, Zachary A.;Haneef, Hamna F.;Jurchescu, Oana D.
通讯作者：
Jurchescu, Oana D.
影响因子：
78.5
作者：
Bernier, J;Hall, EJ;Giaccia, A
通讯作者：
Giaccia, A