Molecular mechanisms underlying neural circuit formation.
Molecular mechanisms underlying neural circuit formation.
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DOI：
10.1016/j.conb.2009.04.004
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发表时间：
2009-04
影响因子：
5.7
通讯作者：
Nose, Akinao
中科院分区：
文献类型：
--
作者：
Lu, Bai;Wang, Kuan Hong;Nose, Akinao
神经系统的功能是由神经回路介导的，这些神经回路是在发育过程中形成的，并受到经验的调节。神经回路组装的核心是突触分子和神经元活动对突触连接性的调节。广泛的研究集中在识别参与突触形成的分子。除了促进突触发生的因子外，还发现了一些抗突触发生的因子。这些因素协同作用，以确保电路形成的时间和特异性。此外，在揭示神经元活动如何支配兴奋性和抑制性突触的平衡方面也取得了进展。有趣的是，几种转录因子，以及通过启动子IV的BDNF的活性依赖性转录，已被证明通过促进GABA能突触的形成来选择性地调节皮质抑制回路。
The functions of the nervous system are mediated by neural circuits that are formed during development and modulated by experiences. Central to the assembly of neural circuits is the regulation of synaptic connectivity by synaptic molecules and neuronal activity. Extensive studies have focused on identifying molecules involved in synapse formation. Besides factors promoting synaptogenesis, several anti-synaptogenic factors have been discovered. These factors act in concert to ensure the timing and specificity of circuit formation. Moreover, progress has been made in revealing how neuronal activity governs the balance of excitatory and inhibitory synapses. Intriguingly, several transcription factors, as well as activity-dependent transcription of BDNF through promoter IV, have been shown to selectively regulate cortical inhibitory circuits by promoting GABAergic synapse formation.
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影响因子：
64.8
作者：
Lin, Yingxi;Bloodgood, Brenda L.;Hauser, Jessica L.;Lapan, Ariya D.;Koon, Alex C.;Kim, Tae-Kyung;Hu, Linda S.;Malik, Athar N.;Greenberg, Michael E.
通讯作者：
Greenberg, Michael E.
影响因子：
16.2
作者：
Chowdhury, Shoaib;Shepherd, Jason D.;Worley, Paul F.
通讯作者：
Worley, Paul F.
影响因子：
16.2
作者：
Lohmann, Christian;Bonhoeffer, Tobias
通讯作者：
Bonhoeffer, Tobias
影响因子：
56.9
作者：
Nedivi, E;Wu, GY;Cline, HT
通讯作者：
Cline, HT
影响因子：
25
作者：
Segura, Inmaculada;Essmann, Clara L.;Acker-Palmer, Amparo
通讯作者：
Acker-Palmer, Amparo