Behavioral patterns and lesion sites associated with impaired processing of lexical and conceptual knowledge of actions.
Behavioral patterns and lesion sites associated with impaired processing of lexical and conceptual knowledge of actions.
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DOI：
10.1016/j.cortex.2010.11.001
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发表时间：
2012-07
期刊：
影响因子：
3.6
通讯作者：
Tranel, Daniel
中科院分区：
文献类型：
--
作者：
Kemmerer, David;Rudrauf, David;Manzel, Ken;Tranel, Daniel
为了进一步研究动作的词汇和概念知识的神经基础，我们对 226 名左右大脑半球损伤广泛分布的脑损伤患者进行了一系列六项任务。这些任务以各种言语和非言语方式探讨动作的词汇和概念知识，包括命名、词图匹配、涉及词和图片的属性判断以及涉及词和图片的联想比较。在接受研究的 226 名患者中，有 61 名患者未能完成六项任务中的一项或多项，其中四名患者的整个电池受到损害，不同数量的患者在不同的任务组合上受到损害。总体而言，61 名患者在六项任务中表现出一系列复杂的关联和分离。还使用正式方法对 226 名患者中的 147 名患者的病变部位进行了病变缺陷统计绘图和病变重叠图的功效分析。在以下左半球区域中发现了所有六项任务的显着影响：额下回；腹侧中央前回，向上延伸至可能与手相关的初级运动区和运动前区；和前岛叶。此外，4-5项任务的显着影响不仅出现在刚才提到的区域，而且还出现在左半球的其他几个区域：腹侧中央后回；边缘上回；和颞中回后部。这些结果与之前关于动作词和概念的神经基础的研究相一致。然而，当前的研究远远超出了之前的大多数研究，为异常庞大且多样化的脑损伤患者样本提供了广泛的行为和病变数据，并结合了动词理解的多种测量方法。关于理论意义，该研究为具身认知框架提供了新的支持，该框架认为概念知识是以感觉运动系统为基础的。
To further investigate the neural substrates of lexical and conceptual knowledge of actions, we administered a battery of six tasks to 226 brain-damaged patients with widely distributed lesions in the left and right cerebral hemispheres. The tasks probed lexical and conceptual knowledge of actions in a variety of verbal and non-verbal ways, including naming, word-picture matching, attribute judgments involving both words and pictures, and associative comparisons involving both words and pictures. Of the 226 patients who were studied, 61 failed one or more of the six tasks, with four patients being impaired on the entire battery, and varied numbers of patients being impaired on varied combinations of tasks. Overall, the 61 patients manifested a complex array of associations and dissociations across the six tasks. The lesion sites of 147 of the 226 patients were also investigated, using formal methods for lesion-deficit statistical mapping and power analysis of lesion overlap maps. Significant effects for all six tasks were found in the following left-hemisphere regions: the inferior frontal gyrus; the ventral precentral gyrus, extending superiorly into what are likely to be hand-related primary motor and premotor areas; and the anterior insula. In addition, significant effects for 4-5 tasks were found in not only the regions just mentioned, but also in several other left-hemisphere areas: the ventral postcentral gyrus; the supramarginal gyrus; and the posterior middle temporal gyrus. These results converge with previous research on the neural underpinnings of action words and concepts. However, the current study goes considerably beyond most previous investigations by providing extensive behavioral and lesion data for an unusually large and diverse sample of brain-damaged patients, and by incorporating multiple measures of verb comprehension. Regarding theoretical implications, the study provides new support for the Embodied Cognition Framework, which maintains that conceptual knowledge is grounded in sensorimotor systems.
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DOI：
10.1523/jneurosci.3039-08.2008
发表时间：
2008-10-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bedny M;Caramazza A;Grossman E;Pascual-Leone A;Saxe R
通讯作者：
Saxe R
影响因子：
5.7
作者：
Bornkessel, I;Zysset, S;Schlesewsky, M
通讯作者：
Schlesewsky, M
影响因子：
9.2
作者：
Aziz-Zadeh, Lisa;Wilson, Stephen M.;Iacoboni, Marco
通讯作者：
Iacoboni, Marco
影响因子：
3.4
作者：
Berlingeri, Manuela;Crepaldi, Davide;Paulesu, Eraldo
通讯作者：
Paulesu, Eraldo
影响因子：
3.6
作者：
Beauchamp, Michael S.;Martin, Alex
通讯作者：
Martin, Alex