Pathogenicity & virulence of Mycoplasma hyopneumoniae.
Pathogenicity & virulence of Mycoplasma hyopneumoniae.
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DOI：
10.1080/21505594.2020.1842659
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发表时间：
2020-12
期刊：
影响因子：
5.2
通讯作者：
Ferreira HB
中科院分区：
文献类型：
--
作者：
Leal Zimmer FMA;Paes JA;Zaha A;Ferreira HB
猪肺炎支原体：是猪地方性肺炎（EP）的病原体，这是一种影响全球养猪业的疾病。病原体引起的损伤以及引起的宿主反应促成疾病。在这里，我们提供了一个概述EP流行病学，控制和预防，并更深入的审查M。病原菌的致病性决定因素，突出病原体-宿主相互作用的发病机制有关的一些分子机制。基于最近的功能，免疫学和比较“组学”的结果，我们讨论了许多已知的或假定的M。猪肺炎支原体毒力因子，沿着与EP有关的宿主分子。此外，已知的致病机制的分子基础，包括M。肺炎支原体对宿主呼吸道上皮细胞的粘附、蛋白质分泌、细胞损伤、宿主杀微生物反应及其调节和维持。描述了感染期间的体液平衡。最近的研究结果关于M。猪肺炎致病性决定因子也有助于开发新的EP诊断试验、疫苗和治疗方法。
Mycoplasma hyopneumoniae: is the etiological agent of porcine enzootic pneumonia (EP), a disease that impacts the swine industry worldwide. Pathogen-induced damage, as well as the elicited host-response, contribute to disease. Here, we provide an overview of EP epidemiology, control and prevention, and a more in-depth review of M. hyopneumoniae pathogenicity determinants, highlighting some molecular mechanisms of pathogen-host interactions relevant for pathogenesis. Based on recent functional, immunological, and comparative “omics” results, we discuss the roles of many known or putative M. hyopneumoniae virulence factors, along with host molecules involved in EP. Moreover, the known molecular bases of pathogenicity mechanisms, including M. hyopneumoniae adhesion to host respiratory epithelium, protein secretion, cell damage, host microbicidal response and its modulation, and maintenance of M. hyopneumoniae homeostasis during infection are described. Recent findings regarding M. hyopneumoniae pathogenicity determinants also contribute to the development of novel diagnostic tests, vaccines, and treatments for EP.
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影响因子：
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作者：
Bhattacharya S;Ploplis VA;Castellino FJ
通讯作者：
Castellino FJ
影响因子：
2.2
作者：
Calsamiglia, M;Pijoan, C
通讯作者：
Pijoan, C
影响因子：
3.6
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通讯作者：
Djordjevic, SP
影响因子：
3.3
作者：
de Oliveira, Natasha Rodrigues;Jorge, Sergio;Dellagostin, Odir Antonio
通讯作者：
Dellagostin, Odir Antonio
影响因子：
3.8
作者：
Dallo, SF;Baseman, JB
通讯作者：
Baseman, JB