Emerging patterns in planarian regeneration.

Emerging patterns in planarian regeneration.
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DOI:
10.1016/j.gde.2009.05.003
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发表时间:
2009-08
影响因子:
4
通讯作者:
Newmark, Phillip A.
Newmark, Phillip A.
中科院分区:
生物学2区
文献类型:
--
作者:
Forsthoefel, David J.;Newmark, Phillip A.

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在过去的十年中,涡虫已成为再生和干细胞生物学研究中越来越容易处理的无脊椎动物模型。该系统中各种技术的应用和基因组试剂的开发使得人们能够探索被称为新生细胞的多能体干细胞补充、修复和再生涡虫组织和器官的分子机制。最近的研究表明,进化上保守的信号通路参与了损伤后前后、背腹和内侧-外侧极性的重建。这些研究极大地增进了我们对涡虫再生过程中早期事件的理解,并提出了关于基于干细胞的组织修复和更新机制的新问题。
In the last decade, the planarian has become an increasingly tractable invertebrate model for the investigation of regeneration and stem cell biology. Application of a variety of techniques and development of genomic reagents in this system have enabled exploration of the molecular mechanisms by which pluripotent somatic stem cells called neoblasts replenish, repair, and regenerate planarian tissues and organs. Recent investigations have implicated evolutionarily conserved signaling pathways in the re-establishment of anterior-posterior, dorsal-ventral, and medial-lateral polarity after injury. These studies have significantly advanced our understanding of early events during planarian regeneration, and have raised new questions about the mechanisms of stem cell-based tissue repair and renewal.
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