Biodistribution of 99mTc-MAA on SPECT/CT performed for 90Y radioembolization therapy planning: a pictorial review.
Biodistribution of 99mTc-MAA on SPECT/CT performed for 90Y radioembolization therapy planning: a pictorial review.
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DOI：
10.1007/s40336-017-0245-8
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发表时间：
2017-10
影响因子：
2.1
通讯作者：
Frey KA
中科院分区：
文献类型：
--
作者：
Bailey JJ;Dewaraja Y;Hubers D;Srinivasa RN;Frey KA
评价90 Y放射栓塞治疗计划期间肝外器官中99 mTc-MAA摄取的频率。该回顾性病例系列包括70例受试者，这些受试者在2014年1月至2016年7月期间在我们机构接受了90年放射性栓塞治疗计划的99 mTc-MAA肝动脉灌注研究，涉及所有受试者的直接图像审查，记录终点：肺分流分数、肝外放射性示踪剂摄取、从MAA注射到成像的时间。70例受试者的合并平面和SPECT/CT成像结果表明，53例（76%）受试者的肺分流分数测量值小于10%，17例（24%）受试者的肺分流分数测量值大于10%。所有患者均显示肾皮质摄取，23例（33%）显示唾液腺摄取，23例（33%）显示甲状腺摄取，32例（46%）显示胃粘膜摄取，这些组之间存在显著重叠。MAA注射和初始成像之间的时间范围为41-138分钟，平均为92分钟。成像时间与任何部位肝外放射性示踪剂摄取之间无相关性。在90 Y放射性栓塞治疗计划的肝动脉灌注扫描期间，肝外摄取很常见，特别是在肾脏、唾液腺、甲状腺和胃粘膜中，并且假设是由99 mTc-MAA随时间的分解引起的。鉴于分解为较小的聚集体并最终形成高锝酸盐，这不应该是实际Y-90微球治疗的禁忌症。虽然我们发现成像时间和肝外摄取之间没有相关性，但我们的大多数注射成像时间相对较短。
To evaluate the frequency of 99mTc-MAA uptake in extrahepatic organs during 90Y radioembolization therapy planning. This retrospective case series of 70 subjects who underwent 99mTc-MAA hepatic artery perfusion studies between January 2014 and July 2016 for 90Y radioembolization therapy planning at our institution involved direct image review for all subjects, with endpoints recorded: lung shunt fraction, extrahepatic radiotracer uptake, time from MAA injection to imaging. Combined planar and SPECT/CT imaging findings in the 70 subjects demonstrated lung shunt fraction measurements of less than 10% in 53 (76%) subjects and greater than 10% in 17 (24%) subjects. All patients demonstrated renal cortical uptake, 23 (33%) demonstrated salivary gland uptake, 23 (33%) demonstrated thyroid uptake, and 32 (46%) demonstrated gastric mucosal uptake, with significant overlap between these groups. The range of elapsed times between MAA injection and initial imaging was 41–138 min, with a mean of 92 min. There was no correlation between time to imaging and the presence of extrahepatic radiotracer uptake at any site. During hepatic artery perfusion scanning for 90Y radioembolization therapy planning, extrahepatic uptake is common, particularly in the kidney, salivary gland, thyroid and gastric mucosa, and is hypothesized to result from breakdown of 99mTc-MAA over time. Given the breakdown to smaller aggregates and ultimately pertechnetate, this should not be a contraindication to actual Y-90 microsphere therapy. Although we found no correlation between time to imaging and extrahepatic uptake, most of our injection to imaging times were relatively short.
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DOI：
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发表时间：
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影响因子：
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DOI：
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发表时间：
2014-11-01
影响因子：
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