Identifying Olfactory Phenotypes to Differentiate Between COVID-19 Olfactory Dysfunction and Sinonasal Inflammatory Disease.
Identifying Olfactory Phenotypes to Differentiate Between COVID-19 Olfactory Dysfunction and Sinonasal Inflammatory Disease.
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DOI：
10.1177/01945998221085500
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发表时间：
2022-11
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影响因子：
--
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中科院分区：
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本研究的目的是确定有或没有嗅觉功能障碍 (OD) 的不同群体的特定嗅觉表型（嗅觉表现模式）。成年患者根据健康状况在 4 组中的 1 组中通过新型嗅觉测试方法进行测试：鼻腔炎症状况（慢性鼻窦炎或过敏性鼻炎）、解决 COVID-19 感染后 ≥ 4 周的自我报告 OD、阿尔茨海默病和健康对照。参与者对每种气味的得分相对于他们的最差和最好得分按 0 到 1 的范围进行标准化。对 COVID-19 和鼻鼻腔队列的标准化数据进行了凝聚层次聚类分析。倒数第二次合并产生的簇显示，检测 COVID-19 患者的敏感性为 81%，特异性为 63%。这些结果支持嗅觉表型可以区分 COVID-19 OD 和鼻窦炎性疾病。这些表型可能会在 OD 患者的检查和治疗中得到越来越多的利用。
The objective of this study was to identify specific olfactory phenotypes—patterns of olfactory performance—across distinct cohorts with or without olfactory dysfunction (OD). Adult patients underwent testing via a novel olfactory testing methodology in 1 of 4 groups based on health status: sinonasal inflammatory condition (chronic rhinosinusitis or allergic rhinitis), ≥4 weeks of self-reported OD after resolved COVID-19 infection, Alzheimer’s disease, and healthy control. Participants’ scores for each scent were normalized on a scale of 0 to 1 relative to their worst and best scores. Agglomerative hierarchal cluster analysis was performed on normalized data for the COVID-19 and sinonasal cohorts. Resulting clusters from the penultimate merger revealed a sensitivity of 81% and specificity of 63% for the detection of patients with COVID-19. These results support that there are olfactory phenotypes that may discriminate COVID-19 OD from sinonasal inflammatory disease. These phenotypes will likely become increasingly leveraged in the workup and treatment of patients with OD.
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