Diet quality indices and postmenopausal breast cancer survival.

Diet quality indices and postmenopausal breast cancer survival.
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DOI:
10.1080/01635581.2011.535963
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发表时间:
2011
期刊:
Nutrition and cancer
影响因子:
--
通讯作者:
Holmes MD
Holmes MD
中科院分区:
其他
文献类型:
--
作者:
Kim EH;Willett WC;Fung T;Rosner B;Holmes MD

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关于乳腺癌生存饮食的研究一直集中在单一营养素或食物上,特别是膳食脂肪、水果、蔬菜、纤维和酒精。我们假设饮食质量指数降低了乳腺癌女性的总死亡率和非乳腺癌相关死亡率。我们评估了4种饮食质量评分:替代健康饮食指数(AHEI),饮食质量指数修订版(DQIR),推荐食物评分(RFS)和替代地中海饮食评分(aMED),这些评分来自护士健康研究,1978年至1998年诊断为浸润性I-III期乳腺癌的2729名女性,随访至2004年。在多变量校正分析中,没有发现饮食质量指数与总的或非乳腺癌相关死亡之间的关联。然而,在低体力活动的女性中,较高的aMED评分与较低的非乳腺癌死亡风险相关;最高与最低三分位数比较的RR为0.39(95%CI,0.20 - 0.75,P趋势= 0.0004)。我们的研究结果表明,乳腺癌诊断后更高质量的饮食不会显著改变乳腺癌死亡的风险。然而,健康的饮食选择可能很重要,因为女性有因饮食影响的非乳腺癌相关原因而死亡的风险。
Research on diet in breast cancer survival has been focused on single nutrients or foods, particularly dietary fat, fruits, vegetables, fiber, and alcohol. We hypothesized that diet quality indices decrease the risk of total and non breast cancer related deaths in women diagnosed with breast cancer. We evaluated 4 dietary quality scores: Alternate Healthy Eating Index (AHEI), Diet Quality Index-Revised (DQIR), Recommended Food Score (RFS), and the alternate Mediterranean Diet Score (aMED), among 2729 women from the Nurses’ Health Study with invasive stage I–III breast cancer diagnosed between 1978 and 1998 with follow up through 2004. In multivariate adjusted analyses, no association was found between diet quality indices and either total or non breast cancer related deaths. However, a higher aMED score was associated with a lower risk of non-breast cancer death in women with low physical activity; the RR comparing the highest to lowest tertile was 0.39 (95% CI, 0.20 – 0.75, P trend = 0.0004). Our results suggest that a higher quality diet after breast cancer diagnosis does not considerably change the risk of death from breast cancer. However, healthy dietary choices may be important because women are at risk of death from non breast cancer-related causes affected by diet.
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