Childhood maltreatment and within-person associations between cortisol and affective experience.
Childhood maltreatment and within-person associations between cortisol and affective experience.
复制标题
DOI：
10.1080/10253890.2021.1928069
复制
发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Young E
中科院分区：
文献类型：
--
作者：
Kuhlman KR;Abelson JL;Mayer SE;Rajaram N;Briggs H;Young E
糖皮质激素对大脑和行为产生深远的影响，但皮质醇浓度很少与人类主观报告的情绪状态有关。本研究旨在探讨皮质醇和主观焦虑之间的联系是否因儿童虐待史而异。为了做到这一点，97人（60.8%的女性）参加了标准化的压力任务在实验室（特里尔社会压力测试，TSST），同时提供了他们的焦虑感以及血液中的皮质醇样本的连续评级。在实验室访视期间，从TSST前即刻至应激开始后65分钟，收集9次这些测量值。我们通过儿童期创伤问卷（CTQ）的自我报告，估计了有和没有儿童期虐待经历的个体的皮质醇浓度和瞬间焦虑感之间的人内关联。儿童时期遭受虐待的人报告说，当皮质醇浓度最低时，他们的焦虑感最强。这种模式在女性参与者、创伤后应激障碍（PTSD）患者以及那些相对于其他形式的虐待而遭受情感忽视的人中被夸大了。早期生活中的逆境，如父母的虐待，可能会改变皮质醇在情感体验中的作用。这一观察结果可能提供了一个新的途径，通过该途径压力可能导致并维持内化症状在人类的初步，翻译的证据。需要更多的研究来解释儿童期虐待在生物行为途径中的调节作用。
Glucocorticoids exert profound effects on the brain and behavior, but cortisol concentrations are rarely linked to subjectively reported emotional states in humans. This study examined whether the link between cortisol and subjective anxiety varied by childhood maltreatment history. To do this, 97 individuals (60.8% female) participated in a standardized stress task in the laboratory (Trier Social Stress Test, TSST) while providing serial ratings of their feelings of anxiety as well as cortisol samples in blood. These measurements were collected nine times across the laboratory visit, from immediately before the TSST to 65 minutes after stress initiation. We estimated the within-person association between cortisol concentrations and momentary feelings of anxiety for individuals with and without exposure to childhood maltreatment, measured via self-report on the Childhood Trauma Questionnaire (CTQ). Individuals exposed to maltreatment during childhood reported the greatest feelings of anxiety when cortisol concentrations were lowest. This pattern was exaggerated among female participants, those with posttraumatic stress disorder (PTSD), and those exposed to emotional neglect relative to other forms of maltreatment. Early life adversity, such as parental maltreatment, may alter the role of cortisol in affective experiences. This observation may provide preliminary, translational evidence of a novel pathway through which stress may lead to and maintain internalizing symptoms in humans. More studies accounting for the moderating role of childhood maltreatment in biobehavioral pathways are needed.
登录
查看更多内容
影响因子：
7.4
作者：
Epel ES;Crosswell AD;Mayer SE;Prather AA;Slavich GM;Puterman E;Mendes WB
通讯作者：
Mendes WB
影响因子：
17.7
作者：
Bogdan, Ryan;Williamson, Douglas E.;Hariri, Ahmad R.
通讯作者：
Hariri, Ahmad R.
影响因子：
3.7
作者：
Hellhammer, Juliane;Schubert, Melanie
通讯作者：
Schubert, Melanie
影响因子：
7.6
作者：
Gerritsen, Lotte;Milaneschi, Yuri;Penninx, Brenda W. J. H.
通讯作者：
Penninx, Brenda W. J. H.
影响因子：
3.2
作者：
KIRSCHBAUM, C;PIRKE, KM;HELLHAMMER, DH
通讯作者：
HELLHAMMER, DH