Does pet-keeping modify the association of delivery mode with offspring body size?
Does pet-keeping modify the association of delivery mode with offspring body size?
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DOI：
10.1007/s10995-014-1649-y
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发表时间：
2015-06
影响因子：
2.3
通讯作者：
Johnson, Christine Cole
中科院分区：
文献类型：
--
作者：
Cassidy-Bushrow, Andrea E.;Wegienka, Ganesa;Havstad, Suzanne;Levin, Albert M.;Lynch, Susan V.;Ownby, Dennis R.;Rundle, Andrew G.;Woodcroft, Kimberley J.;Zoratti, Edward M.;Johnson, Christine Cole
剖腹产（CS）分娩增加了儿童肥胖的风险，并且与可能导致肥胖的独特的早期肠道微生物组相关。家庭宠物可能会改变人类肠道微生物组的组成。我们在639名韦恩县健康、环境、过敏和哮喘纵向研究（WHEALS）出生队列参与者中检查了饲养宠物是否改变了CS与2岁时肥胖的关联。养宠物定义为在2岁时养狗或猫（室内≥1小时/天）。我们使用逻辑回归来检验CS和饲养宠物与2岁时肥胖（BMI≥第95百分位数）之间的相互作用，并对母亲肥胖进行了调整。共有328名（51.3%）儿童为男性; 367名（57.4%）为非洲裔美国人; 228名（35.7%）为CS出生; 55名（8.6%）为肥胖。校正母亲肥胖后，CS出生的儿童与阴道出生的儿童相比，肥胖几率无显著性差异（P=0.25），但升高了1.4（95%CI：0.8，2.5）。有证据表明，目前的宠物饲养和分娩模式与2岁时的肥胖症之间存在效果差异（相互作用P=0.054）。与目前家中没有宠物的阴道出生的儿童相比，目前家中没有宠物的通过CS出生的儿童在2岁时肥胖的几率在统计学上显著更高（P=0.043）（比值比=2.00; 95% CI：1.02，3.93）。宠物改变了CS-BMI关系;潜在的机制是否是通过对环境或肠道微生物组的影响需要具体的研究。
Caesarean-section (CS) delivery increases risk of childhood obesity, and is associated with a distinct early-life gut microbiome, which may contribute to obesity. Household pets may alter human gut microbiome composition. We examined if pet-keeping modified the association of CS with obesity at age 2 years in 639 Wayne County Health, Environment, Allergy and Asthma Longitudinal Study (WHEALS) birth cohort participants. Pet-keeping was defined as having a dog or cat (indoors ≥1 hour/day) at child age 2 years. We used logistic regression to test for an interaction between CS and pet-keeping with obesity (BMI≥95th percentile) at age 2 years, adjusted for maternal obesity. A total of 328 (51.3%) children were male; 367 (57.4%) were African American; 228 (35.7%) were born by CS; and 55 (8.6%) were obese. After adjusting for maternal obesity, CS-born children had a non-significant (P=0.25) but elevated 1.4 (95% CI: 0.8, 2.5) higher odds of obesity compared to those born vaginally. There was evidence of effect modification between current pet-keeping and delivery mode with obesity at age 2 years (interaction P=0.054). Compared to children born vaginally without a pet currently in the home, children born via CS without a pet currently in the home had a statistically significant (P=0.043) higher odds (odds ratio=2.00; 95% CI: 1.02, 3.93) of being obese at age 2 years. Pets modified the CS-BMI relationship; whether the underlying mechanism is through effects on environmental or gut microbiome requires specific investigation.
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DOI：
10.1186/1710-1492-9-15
发表时间：
2013
期刊：
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
影响因子：
--
作者：
Azad MB;Konya T;Maughan H;Guttman DS;Field CJ;Sears MR;Becker AB;Scott JA;Kozyrskyj AL
通讯作者：
Kozyrskyj AL
影响因子：
7.1
作者：
Flores, Glenn;Lin, Hua
通讯作者：
Lin, Hua
影响因子：
3.6
作者：
Balamurugan, Ramadass;George, Gemlyn;Ramakrishna, Balakrishnan S.
通讯作者：
Ramakrishna, Balakrishnan S.
影响因子：
4.9
作者：
Blustein, J.;Attina, T.;Liu, M.;Ryan, A. M.;Cox, L. M.;Blaser, M. J.;Trasande, L.
通讯作者：
Trasande, L.
DOI：
10.1073/pnas.1310750111
发表时间：
2014-01-14
影响因子：
11.1
作者：
Fujimura, Kei E.;Demoor, Tine;Lynch, Susan V.
通讯作者：
Lynch, Susan V.