Anterior genu corpus callosum and impulsivity in suicidal patients with bipolar disorder.
Anterior genu corpus callosum and impulsivity in suicidal patients with bipolar disorder.
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双相情感障碍自杀患者的前膝胼胝体和冲动。
DOI：
10.1016/j.neulet.2009.11.047
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发表时间：
2010-01-18
影响因子：
2.5
通讯作者：
Soares JC
中科院分区：
文献类型：
--
作者：
Matsuo K;Nielsen N;Nicoletti MA;Hatch JP;Monkul ES;Watanabe Y;Zunta-Soares GB;Nery FG;Soares JC
自杀是双相情感障碍（BD）患者的一种危及生命的症状。冲动和情绪不稳定与心境障碍中的自杀倾向有关。有证据表明，灰色和白色物质异常与情绪障碍的冲动性有关，但对胼胝体（CC）和BD的冲动性之间的关联知之甚少。我们研究了BD患者CC区、冲动性和自杀倾向之间的关系。研究对象为10例有自杀未遂史的女性BD患者（平均年龄36.2± 10.1岁）、10例无自杀未遂史的女性BD患者（44.2± 12.5岁）和27例女性健康者（36.9± 13.8岁）。冲动性通过Barratt冲动性量表（BIS）进行评估。我们追踪MR图像，测量CC骨、前体、后体、峡部和压部的面积。视神经可分为前、中、后区。有自杀倾向和无自杀倾向的BD患者的BIS总分、注意力和非计划性评分均显著高于健康对照组（P <0.01），有自杀倾向的BD患者的BIS运动评分显著高于无自杀倾向的BD患者和健康对照组（P <0.01）。三组之间在任何区域CC面积上均无显著差异，尽管自杀性BD患者的面积最小。有自杀倾向的BD患者的前额叶面积与BIS总分（r=-0.75，p=0.04）、运动（r=-0.79，p=0.02）和非计划性评分（r=-0.79，p=0.02）呈显著负相关。在非自杀性BD患者或健康受试者中未发现这些相关性。结果表明，前内侧额叶区可能参与BD的冲动和自杀行为的病理生理。
Suicidality is a life-threatening symptom in patients with bipolar disorder (BD). Impulsivity and mood instability are associated with suicidality in mood disorders. Evidence suggests that gray and white matter abnormalities are linked with impulsivity in mood disorders, but little is known about the association between corpus callosum (CC) and impulsivity in BD. We examined the relationship between CC areas, impulsivity and suicidality in BD patients. We studied 10 female BD patients with a history of suicide attempt (mean±sd age 36.2±10.1y), 10 female BD patients without suicide attempt history (44.2±12.5y) and 27 female healthy subjects (36.9±13.8y). Impulsivity was evaluated by the Barratt Impulsivity Scale (BIS). We traced MR images to measure the areas of the CC genu, anterior body, posterior body, isthmus and splenium. The genu was divided into anterior, middle and posterior regions. The suicidal and non-suicidal BD patients had significantly higher BIS total, attention and non-planning scores than the healthy subjects (Ps<0.01), and the suicidal BD patients had significantly higher BIS motor scores than the non-suicidal BD and healthy subjects (Ps<0.01). There were no significant differences among the three groups on any regional CC areas, although the suicidal BD patients had the smallest areas. The suicidal BD patients showed a significant inverse correlation between anterior genu area and the BIS total (r=−0.75, p=0.04), motor (r=−0.79, p=0.02) and non-planning scores (r=−0.79, p=0.02). These correlations were not found in the non-suicidal BD patients or healthy subjects. The results suggest that the anterior medial frontal region may be involved in the pathophysiology of impulsive and suicidal behaviors in BD.
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影响因子：
6.6
作者：
Caetano, Sheila C.;Silveira, Camila Magalhaes;Soares, Jair C.
通讯作者：
Soares, Jair C.
影响因子：
6.6
作者：
Ehrlich, S;Breeze, JL;Renshaw, PF
通讯作者：
Renshaw, PF
影响因子：
4.8
作者：
Matsuo, Koji;Nicoletti, Mark;Soares, Jair C.
通讯作者：
Soares, Jair C.
DOI：
10.1007/s00406-007-0755-x
发表时间：
2007-12-01
影响因子：
4.7
作者：
Pompili, Maurizio;Ehrlich, Stefan;Girardi, Paolo
通讯作者：
Girardi, Paolo
影响因子：
7.6
作者：
Ballmaier, Martina;Kumar, Anand;Toga, Arthur W.
通讯作者：
Toga, Arthur W.