Mitigating Disease Impacts in Amphibian Populations: Capitalizing on the Thermal Optimum Mismatch Between a Pathogen and Its Host
Mitigating Disease Impacts in Amphibian Populations: Capitalizing on the Thermal Optimum Mismatch Between a Pathogen and Its Host
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减轻疾病对两栖动物种群的影响：利用病原体与其宿主之间的热最佳不匹配
DOI：
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发表时间：
2019
影响因子：
3
通讯作者：
J. Bosch
中科院分区：
文献类型：
--
作者：
A. Hettyey;J. Ujszegi;D. Herczeg;D. Holly;J. Vörös;B. R. Schmidt;J. Bosch
了解动物行为如何影响濒危宿主对新出现病原体的易感性，并利用这些知识来改善传染性野生动物疾病的负面影响，是保护生物学的一条有前途的途径。壶菌病是一种由真菌性病原菌引起的两栖动物传染病，已导致脊椎动物生物多样性的严重丧失。不幸的是，今天可用的缓解方法仅适用于圈养种群，并且缺乏一种可以应用于自然栖息地而不会造成巨大附带损害的有效方法。我们在这里建议，Bd和它的变温主机之间的热耐受性不匹配，加上两栖动物的体温调节行为，可以利用缓解干预措施，打击Bd感染原位。如果在自然环境中提供具有高温的微生境，那么利用达到其首选体温的可能性的个体可以大大降低其感染强度，甚至清除病原体。我们提供了一个研究这种方法的基础，通过审查支持这一想法的证据，描述如何克服技术困难，指出我们的知识差距，需要填补未来的研究，并列出假定贝内和可能的局限性局部加热。所提出的方法有很好的潜力，成为一个有效的就地缓解方法，可以很容易地在广泛的两栖动物分类范围，特别是在物种的温暖适应，同时造成较少的附带损害比任何其他方法，目前可用。如果是这样的话，它可能很快成为一个广泛适用的生物多样性保护工具，并可能有助于拯救许多两栖动物种群和物种在未来几十年内灭绝。
Understanding how animal behavior can influence the susceptibility of endangered hosts to emerging pathogens and using this knowledge to ameliorate negative effects of infectious wildlife diseases is a promising avenue in conservation biology. Chytridiomycosis, an emerging infectious disease caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd) in amphibians has led to the most spectacular disease-borne loss of vertebrate biodiversity ever recorded in history. Unfortunately, the methods of mitigation that are available today are only practical in captive populations, and an effective method that could be applied in natural habitats without inflicting vast collateral damage is lacking. We suggest here that the thermal tolerance mismatch between Bd and its ectothermic hosts coupled with the thermoregulatory behavior of amphibians could be exploited in mitigation interventions combating Bd infection in situ. If microhabitats with elevated temperatures are made available in their natural environment, individuals taking advantage of the possibility to reach their preferred body temperature could critically lower their infection intensity or even clear the pathogen. We provide a basis for studying this approach by reviewing the evidence that supports the idea, describing how technical difficulties may be overcome, pointing out gaps in our knowledge that need to be filled by future studies, and listing presumable bene fits and probable limitations of localized heating. The proposed approach has good potential to become an effective in situ mitigation method that can be easily employed in a wide taxonomic range of amphibians, especially in species that are warm-adapted, while causing less collateral damage than any other method that is currently available. If so, it may quickly become a widely applicable tool of biodiversity conservation and may contribute to saving many amphibian populations and species from extinction in the next few decades.
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影响因子：
8.8
作者：
Cohen, Jeremy M.;Venesky, Matthew D.;Rohr, Jason R.
通讯作者：
Rohr, Jason R.
DOI：
10.1101/473934
发表时间：
2018-11
期刊：
bioRxiv
影响因子：
--
作者：
Jeremy M. Cohen;T. McMahon;Chloe Ramsay;E. A. Roznik;Erin L. Sauer;S. Bessler;D. Civitello;Bryan K. Delius;Neal T Halstead;Sarah A. Knutie;K. Nguyen;Nicole Ortega;B. Sears;Matthew D. Venesky;S. Young;Jason Rohr
通讯作者：
Jeremy M. Cohen;T. McMahon;Chloe Ramsay;E. A. Roznik;Erin L. Sauer;S. Bessler;D. Civitello;Bryan K. Delius;Neal T Halstead;Sarah A. Knutie;K. Nguyen;Nicole Ortega;B. Sears;Matthew D. Venesky;S. Young;Jason Rohr
影响两栖动物壶菌病易感性的因素是个体温度偏好的变化，而不是行为发热
DOI：
10.1098/rspb.2018.1111
发表时间：
2018
期刊：
Proceedings of the Royal Society B: Biological Sciences
影响因子：
--
作者：
Sauer, Erin L.;Fuller, Rebecca C.;Richards-Zawacki, Corinne L.;Sonn, Julia;Sperry, Jinelle H.;Rohr, Jason R.
通讯作者：
Rohr, Jason R.
DOI：
10.1073/pnas.1111915108
发表时间：
2011-11-15
影响因子：
11.1
作者：
Farrer, Rhys A.;Weinert, Lucy A.;Fisher, Matthew C.
通讯作者：
Fisher, Matthew C.
影响因子：
11.6
作者：
Cohen, Jeremy M.;Civitello, David J.;Rohr, Jason R.
通讯作者：
Rohr, Jason R.