The spleen contributes to stroke-induced neurodegeneration.
The spleen contributes to stroke-induced neurodegeneration.
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DOI：
10.1002/jnr.21661
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发表时间：
2008-08-01
影响因子：
4.2
通讯作者：
Pennypacker, Keith R.
中科院分区：
文献类型：
--
作者：
Ajmo, Craig T., Jr.;Vernon, Dionne O. L.;Collier, Lisa;Hall, Aaron A.;Garbuzova-Davis, Svitlana;Willing, Alison;Pennypacker, Keith R.
中风是一种脑血管损伤，是世界上致残的首要原因和死亡的第三大原因。最近的报道表明，抑制中风后的炎症反应可以提高神经存活率，限制梗塞的扩大。在脾中启动的免疫反应与中风的全身炎症反应有关，从而导致神经退化。在这里，我们发现切除脾可以显著减少缺血性损伤后的神经退行性变。在永久性大脑中动脉闭塞前2周切除脾的大鼠，与那些只接受中风手术的大鼠相比，大脑中的脑梗塞体积减少了80%。脾切除还导致脑组织中激活的小胶质细胞、巨噬细胞和中性粒细胞数量减少。我们的结果表明，由脾介导的外周免疫反应是中风后促进神经变性的炎症的主要贡献者。
Stroke, a cerebrovascular injury, is the leading cause of disability and third leading cause of death in the world. Recent reports indicate that inhibiting the inflammatory response to stroke enhances neurosurvival and limits expansion of the infarction. The immune response that is initiated in the spleen has been linked to the systemic inflammatory response to stroke, contributing to neurodegeneration. Here we show that removal of the spleen significantly reduces neurodegeneration after ischemic insult. Rats splenectomized 2 weeks before permanent middle cerebral artery occlusion had a >80% decrease in infarction volume in the brain compared with those rats that were subjected to the stroke surgery alone. Splenectomy also resulted in decreased numbers of activated microglia, macrophages, and neutrophils present in the brain tissue. Our results demonstrate that the peripheral immune response as mediated by the spleen is a major contributor to the inflammation that enhances neurodegeneration after stroke.
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DOI：
10.1007/bf03160109
发表时间：
1995-01-01
期刊：
MOLECULAR AND CHEMICAL NEUROPATHOLOGY
影响因子：
--
作者：
BARONE, FC;HILLEGASS, LM;SARAU, HM
通讯作者：
SARAU, HM
DOI：
10.1073/pnas.0400569101
发表时间：
2004-06-22
影响因子：
11.1
作者：
Benner, EJ;Mosley, RL;Gendelman, HE
通讯作者：
Gendelman, HE
影响因子：
2.9
作者：
Duckworth, EAM;Butler, TL;Pennypacker, KR
通讯作者：
Pennypacker, KR
影响因子：
2.9
作者：
Hausmann, EHS;Berman, NEJ;Klein, RM
通讯作者：
Klein, RM
DOI：
10.1124/jpet.102.035048
发表时间：
2003-01-01
影响因子：
3.5
作者：
Liu, B;Hong, JS
通讯作者：
Hong, JS