The innate immune response in house dust mite-induced allergic inflammation.
The innate immune response in house dust mite-induced allergic inflammation.
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DOI：
10.4168/aair.2013.5.2.68
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发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
Wang JY
中科院分区：
文献类型：
--
作者：
Wang JY
Hypersensitivity to house dust mite (HDM; Dermatophagoides sp.) allergens is one of the most common allergic responses, affecting up to 85% of asthmatics. Sensitization to indoor allergens is the strongest independent risk factor associated with asthma. Additionally, >50% of children and adolescents with asthma are sensitized to HDM. Although allergen-specific CD4+ Th2 cells orchestrate the HDM allergic response through induction of IgE directed toward mite allergens, activation of innate immunity also plays a critical role in HDM-induced allergic inflammation. This review highlights the HDM components that lead to activation of the innate immune response. Activation may due to HDM proteases. Proteases may be recognized by protease-activation receptors (PARs), Toll-like receptors (TLRs), or C-type lectin receptors (CTRs), or act as a molecular mimic for PAMP activation signaling pathways. Understanding the role of mite allergen-induced innate immunity will facilitate the development of therapeutic strategies that exploit innate immunity receptors and associated signaling pathways for the treatment of allergic asthma.
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DOI：
10.1006/bbrc.1996.0544
发表时间：
1996-04-05
影响因子：
3.1
作者：
Kalsheker, NA;Deam, S;Lomas, DA
通讯作者：
Lomas, DA
影响因子：
12.4
作者：
Li, J.;Sun, B.;Zhong, N.
通讯作者：
Zhong, N.
影响因子：
8
作者：
Huang, H-J;Lin, Y-L;Wang, J-Y
通讯作者：
Wang, J-Y
影响因子：
14.2
作者：
Chen, Chih-Lung;Wang, Shulhn-Der;Wang, Jiu-Yao
通讯作者：
Wang, Jiu-Yao
影响因子：
2.8
作者：
Cunningham，Paula T.;Elliot，Claire E.;Thomas，Wayne R.
通讯作者：
Thomas，Wayne R.