Cumulative survival in early-onset unilateral and bilateral breast cancer: an analysis of 1907 Taiwanese women.
Cumulative survival in early-onset unilateral and bilateral breast cancer: an analysis of 1907 Taiwanese women.
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DOI：
10.1038/sj.bjc.6604898
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发表时间：
2009-02-24
影响因子：
8.8
通讯作者：
Tsau, H-S
中科院分区：
文献类型：
--
作者：
Kuo, W-H;Yen, A. M-F;Lee, P-H;Chen, K-M;Wang, J.;Chang, K-J;Chen, T. H-H;Tsau, H-S
关键词：
由于现代化亚洲国家的乳腺癌流行病学模式与西方国家有很大不同，因此值得研究这些国家单侧和双侧乳腺癌的长期发病率。本研究以1907位台湾女性为研究对象，追踪1863位单侧及44位双侧乳癌病例。时间依赖性考克斯回归被用来评估乳腺癌死亡的风险，考虑单侧和双侧肿瘤发展的时间过程。单侧、同时双侧和异时双侧乳腺癌的15年生存率分别为68.37%、62.63%和26.42%。在5年的随访中，类型之间的差异最为明显。在调整了重要的预后因素后，双侧乳腺癌的死亡风险是单侧乳腺癌的2.50倍（95%CI，1.43-4.37）。同期和异时双侧乳腺癌的相应数字分别为1.12倍（95%CI，0.42-3.02）和6.11倍（95%CI，3.14-11.89）。台湾妇女，谁是经常被诊断为乳腺癌在50岁之前，表现出较差的生存异时性双侧比同期双侧或单侧乳腺癌。与瑞典最近的数据相比，生存率明显较差。
As the epidemiological pattern of breast cancer in modernising Asian countries differs greatly from that in Western countries, it is worthwhile to investigate the long-term prognoses of unilateral and bilateral breast cancer in these nations. A retrospective cohort study composed of 1907 Taiwanese women was conducted to follow 1863 unilateral and 44 bilateral cases of breast cancer. Time-dependent Cox regression was used to assess the risk of breast cancer death by considering the time course of unilateral and bilateral tumour development. The 15-year survival rates were 68.37, 62.63, and 26.42% for unilateral, synchronous bilateral, and metachronous bilateral breast cancer, respectively. Differences among types were most apparent after 5 years of follow-up. After adjusting for significant prognostic factors, the risk of death for overall bilateral breast cancer was 2.50-fold greater (95% CI, 1.43–4.37) compared to unilateral breast cancer. The corresponding figures were 1.12-fold (95% CI, 0.42–3.02) and 6.11-fold (95% CI, 3.14–11.89) for synchronous and metachronous bilateral breast cancer, respectively. Taiwanese women, who are frequently diagnosed with breast cancer before 50 years of age, showed poorer survival for metachronous bilateral than for synchronous bilateral or unilateral breast cancer. Survival was markedly poorer compared to recent data from Sweden.
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影响因子：
6.4
作者：
Minami, Y;Tsubono, Y;Hisamichi, S
通讯作者：
Hisamichi, S
影响因子：
2.2
作者：
Rubinstein, Wendy S
通讯作者：
Rubinstein, Wendy S
DOI：
10.1111/j.1445-2197.1989.tb01462.x
发表时间：
1989-01-01
期刊：
AUSTRALIAN AND NEW ZEALAND JOURNAL OF SURGERY
影响因子：
--
作者：
ALEXANDER, AI;MERCER, RJ;HOLDAWAY, I
通讯作者：
HOLDAWAY, I
影响因子：
--
作者：
Leung, Amy W. H.;Mak, Joyce;Epstein, Richard J.
通讯作者：
Epstein, Richard J.
影响因子：
2.6
作者：
Kollias, J;Ellis, IO;Blamey, RW
通讯作者：
Blamey, RW