Prognostic effect of matrix metalloproteinase-9 in patients with resected Non small cell lung cancer.
Prognostic effect of matrix metalloproteinase-9 in patients with resected Non small cell lung cancer.
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DOI：
10.1186/s13019-015-0248-3
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发表时间：
2015-03-27
影响因子：
1.6
通讯作者：
Chung KY
中科院分区：
文献类型：
--
作者：
Lee CY;Shim HS;Lee S;Lee JG;Kim DJ;Chung KY
肿瘤基质金属蛋白酶-9(MMP9)在非小细胞肺癌(NSCLC)中的表达仍存在争议。在这项研究中，我们研究了肿瘤基质金属蛋白酶-9的表达和其他临床病理因素在完全切除的非小细胞肺癌患者中的预后价值。这项回顾性研究包括1998至2009年间在韩国首尔西弗兰斯医院接受病理I-IIIA期非小细胞肺癌完全切除的患者。对417例肿瘤标本进行免疫组织化学染色，以免疫组织化学中位数10(范围0~300)为界，评价肿瘤细胞中基质金属蛋白酶-9的表达。417例患者中有161例(38.6%)表达肿瘤基质金属蛋白酶-9。LOG-RANK分析显示，肿瘤基质金属蛋白酶-9的表达与缩短的无病生存期显著相关(p = 0.109)，但与总生存期无关(p = 0.01)。多因素分析显示，肿瘤基质金属蛋白酶-9的表达不是影响复发(p = 0.142)或生存(p = 0.807)的独立预后因素。然而，在腺癌患者中，肿瘤基质金属蛋白酶-9的表达与复发(p = 0.003)和较差的生存(p = 0.033)相关。此外，肿瘤基质金属蛋白酶-9的表达是腺癌患者复发的独立预后指标(p = 0.035)。在非小细胞肺癌患者中，腺癌患者中肿瘤基质金属蛋白酶-9的表达与不良预后相关，而鳞癌患者中则不相关。此外，MMP-9的表达被确认为完全切除的肺腺癌复发的独立预测因子。
The role of tumor matrix metalloproteinase-9 (MMP-9) expression in non-small cell lung cancer (NSCLC) remains controversial. In this study, we investigated the prognostic value of tumor MMP-9 expression and other clinicopathologic factors in patients with completely resected NSCLC. This retrospective study included patients who underwent complete resection of pathological stage I–IIIA NSCLC at Severance Hospital, Seoul, Korea, between 1998 and 2009. Tumor samples of 417 patients were stained by immunohistochemistry, and the expression of MMP-9 in tumor cells was evaluated, using the median immunohistochemical score of 10 (range, 0-300) as the cut-off. Tumor MMP-9 expression was observed in 161 (38.6%) of 417 patients. Log-rank analysis showed a significant association of tumor MMP-9 expression with shortened disease-free survival (p = 0.01) but not with overall survival (p = 0.109). Multivariate analysis demonstrated that tumor MMP-9 expression was not an independent prognostic factor of recurrence (p = 0.142) or survival (p = 0.807). However, among patients with adenocarcinoma, tumor MMP-9 expression was associated with relapse (p = 0.003) and poor survival (p = 0.033). Furthermore, tumor MMP-9 expression was an independent prognostic indicator of relapse in patients with adenocarcinoma (p = 0.035). Among patients with NSCLC, tumor MMP-9 expression was associated with poor outcomes in those with adenocarcinoma, but not in those with squamous cell carcinoma. In addition, MMP-9 expression was identified as an independent predictor of relapse of completely resected lung adenocarcinoma.
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影响因子：
5.3
作者：
Fujise, N;Nanashima, A;Ayabe, H
通讯作者：
Ayabe, H
影响因子：
51.1
作者：
Pirker, Robert;Pereira, Jose R.;O'Byrne, Kenneth J.
通讯作者：
O'Byrne, Kenneth J.
影响因子：
5.3
作者：
Liu, Dage;Nakano, Jun;Huang, Cheng-long
通讯作者：
Huang, Cheng-long
影响因子：
3.8
作者：
Tian, Mei;Cui, Ya-Zhou;Song, Guan-Hua;Zong, Mei-Juan;Zhou, Xiao-Yan;Chen, Yu;Han, Jin-Xiang
通讯作者：
Han, Jin-Xiang
影响因子：
6.4
作者：
Wu, Zheng-Sheng;Wu, Qiang;Xu, Xiao-Chun
通讯作者：
Xu, Xiao-Chun