Silk Fibroin as a Functional Biomaterial for Tissue Engineering.
Silk Fibroin as a Functional Biomaterial for Tissue Engineering.
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DOI：
10.3390/ijms22031499
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发表时间：
2021-02-02
影响因子：
5.6
通讯作者：
Zhao X
中科院分区：
文献类型：
--
作者：
Sun W;Gregory DA;Tomeh MA;Zhao X
组织工程（tissue engineering，TE）是将联合收割机细胞与支架材料和适当的生长因子结合，以再生或替代受损或退化的组织或器官的方法。支架材料作为组织形成的模板在TE中起着最重要的作用。在支架材料中，丝素蛋白（SF）是一种具有优异机械性能、生物降解性、生物相容性和生物可吸收性的天然蛋白质，在TE应用中引起了极大的关注。SF通常溶解在水溶液中，并且可以通过各种制造技术容易地重建成不同的材料形式，包括膜、垫、水凝胶和海绵。这些包括旋涂、静电纺丝、冷冻干燥、物理和化学交联技术。此外，为了便于用高精度技术制造更复杂的基于SF的支架，最近已经探索了包括微图案化和生物印刷的技术。本文介绍了SF的物理化学和力学性能，并展望了一系列SF为基础的支架，最近开发的。SF基支架的典型TE应用包括骨、软骨、韧带、肌腱、皮肤、伤口愈合和鼓膜，将被强调和讨论，随后是未来的前景和需要解决的挑战。
Tissue engineering (TE) is the approach to combine cells with scaffold materials and appropriate growth factors to regenerate or replace damaged or degenerated tissue or organs. The scaffold material as a template for tissue formation plays the most important role in TE. Among scaffold materials, silk fibroin (SF), a natural protein with outstanding mechanical properties, biodegradability, biocompatibility, and bioresorbability has attracted significant attention for TE applications. SF is commonly dissolved into an aqueous solution and can be easily reconstructed into different material formats, including films, mats, hydrogels, and sponges via various fabrication techniques. These include spin coating, electrospinning, freeze drying, physical, and chemical crosslinking techniques. Furthermore, to facilitate fabrication of more complex SF-based scaffolds with high precision techniques including micro-patterning and bio-printing have recently been explored. This review introduces the physicochemical and mechanical properties of SF and looks into a range of SF-based scaffolds that have been recently developed. The typical TE applications of SF-based scaffolds including bone, cartilage, ligament, tendon, skin, wound healing, and tympanic membrane, will be highlighted and discussed, followed by future prospects and challenges needing to be addressed.
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