Utility of animal and in vivo experimental infection of humans with rhinoviruses in the development of therapeutic agents for viral exacerbations of asthma and chronic obstructive pulmonary disease.
Utility of animal and in vivo experimental infection of humans with rhinoviruses in the development of therapeutic agents for viral exacerbations of asthma and chronic obstructive pulmonary disease.
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DOI：
10.1016/j.pupt.2014.10.005
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发表时间：
2015-03
影响因子：
3.2
通讯作者：
Turner RB
中科院分区：
文献类型：
--
作者：
Del Vecchio AM;Branigan PJ;Barnathan ES;Flavin SK;Silkoff PE;Turner RB
与呼吸道急性病毒感染、哮喘和慢性阻塞性肺病（COPD）恶化有关。尽管这些急性加重与几种类型的病毒有关，但人鼻病毒（HRV）与绝大多数疾病急性加重有关。由于缺乏天然允许HRV用作简易模型系统的动物物种，以及与哮喘和COPD动物模型相关的限制，使用HRV对人类进行受控实验感染的研究已经安全地使用和进行了数十年。这篇综述讨论了这些实验性感染研究与HRV如何提供了一种手段，了解潜在的病毒引起的哮喘和COPD急性加重的病理生理学，其目标是开发药物，用于预防和治疗。
There is an association with acute viral infection of the respiratory tract and exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Although these exacerbations are associated with several types of viruses, human rhinoviruses (HRVs) are associated with the vast majority of disease exacerbations. Due to the lack of an animal species that is naturally permissive for HRVs to use as a facile model system, and the limitations associated with animal models of asthma and COPD, studies of controlled experimental infection of humans with HRVs have been used and conducted safely for decades. This review discusses how these experimental infection studies with HRVs have provided a means of understanding the pathophysiology underlying virus-induced exacerbations of asthma and COPD with the goal of developing agents for their prevention and treatment.
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DOI：
10.1007/978-1-4939-1571-2_6
发表时间：
2015-01-01
期刊：
RHINOVIRUSES: METHODS AND PROTOCOLS
影响因子：
--
作者：
Ashraf, Shamaila;Brockman-Schneider, Rebecca;Gern, James E.
通讯作者：
Gern, James E.
影响因子：
11.8
作者：
Alper, CM;Doyle, WJ;Gwaltney, JM
通讯作者：
Gwaltney, JM
影响因子：
8
作者：
Akinbami, Lara J.;Moorman, Jeanne E.;Sondik, Edward J.
通讯作者：
Sondik, Edward J.
影响因子：
11.1
作者：
Bartlett, Nathan W.;Slater, Louise;Edwards, Michael R.
通讯作者：
Edwards, Michael R.
DOI：
10.1164/ajrccm/144.6.1267
发表时间：
1991-12-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
CALHOUN, WJ;SWENSON, CA;BUSSE, WW
通讯作者：
BUSSE, WW