Transient Epileptic Amnesia over twenty years: Long-term follow-up of a case series with three detailed reports.
Transient Epileptic Amnesia over twenty years: Long-term follow-up of a case series with three detailed reports.
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DOI：
10.1016/j.seizure.2016.10.022
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Zeman AZ
中科院分区：
文献类型：
--
作者：
Savage SA;Butler CR;Hodges JR;Zeman AZ
短暂性癫痫健忘症(TEA)是一种以发作性健忘症为特征的成人起病的颞叶癫痫。失忆发作常伴有间歇性记忆障碍，表现为自传性遗忘和加速的长期遗忘。短期随访研究表明，一旦接受治疗，认知状况相对稳定，但最近的病例报告提出了对发展为阿尔茨海默病(AD)的风险的担忧。目前的研究报告了20年来TEA患者的临床和认知结果。对1998年首次报告的10名TEA患者进行了两次随访，每隔10年进行一次随访。通过GP记录和临床访谈获得有关临床结果和记忆功能的主观报告的信息。目的在可能的情况下，在每个时间点通过全面的神经心理评估来测定记忆功能。获得了最初10名参与者中9名的信息。在20年的时间里，4名参与者死亡，死亡前没有痴呆症的迹象。一名参与者被诊断为血管性痴呆。癫痫发作总体上得到了良好的控制。记忆的主观报告各不相同，包括无顾虑、稳定性记忆困难和记忆恶化。10年后的神经心理评估显示，在大多数指标上都表现稳定。在20年的随访中，没有证据表明认知能力普遍下降。与会者在一些指标上表现出稳定，在其他指标上有所减少。表现与AD不一致。从这一系列茶叶中没有明显增加患痴呆症的风险。尽管记忆障碍会随着时间的推移而持续存在，但TEA的预后通常看起来是良性的。
Transient Epileptic Amnesia (TEA) is a form of adult onset temporal lobe epilepsy characterised by ictal amnesia. The amnesic seizures are often accompanied by interical memory disturbance, involving autobiographical amnesia and accelerated long-term forgetting. Short-term follow-up studies suggest a relatively stable cognitive profile once treated, but recent case reports raise concerns regarding the risk of developing Alzheimer’s Disease (AD). The current study reports clinical and cognitive outcome in TEA patients over a 20-year period. A cohort of ten TEA patients first reported in 1998 were followed up at two time intervals, each 10 years apart. Information regarding clinical outcomes and subjective reports of memory functioning was gained via GP records and clinical interview. Objective memory function was determined at each time point via a comprehensive neuropsychological assessment, where possible. Information was obtained for nine of the original 10 participants. Over the 20-year period, 4 participants died, with no indication of dementia prior to death. One participant was diagnosed with Vascular Dementia. Seizures were generally well controlled. Subjective reports of memory varied, including no concerns, stable memory difficulties, and worsening memory. Neuropsychological assessment at 10 years showed stable performances across most measures. At the 20-year follow up, there was no evidence of a general cognitive decline. Participants showed stability on some measures, with reductions on others. Performance was not consistent with AD. No elevated risk of dementia was evident from this TEA series. Although memory difficulties persist over time, the prognosis of TEA appears generally benign.
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影响因子：
11
作者：
MCKENNA, P;WARRINGTON, EK
通讯作者：
WARRINGTON, EK
影响因子：
14.5
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2.6
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影响因子：
168.9
作者：
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14.5
作者：
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