Adjuvanted Influenza Vaccines Elicits Higher Antibody Responses against the A(H3N2) Subtype than Non-Adjuvanted Vaccines.

Adjuvanted Influenza Vaccines Elicits Higher Antibody Responses against the A(H3N2) Subtype than Non-Adjuvanted Vaccines.
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DOI:
10.3390/vaccines8040704
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发表时间:
2020-11-25
期刊:
影响因子:
7.8
通讯作者:
Eiros Bouza JM
Eiros Bouza JM
中科院分区:
医学3区
文献类型:
--
作者:
Sánchez de Prada L;Sanz Muñoz I;Castrodeza Sanz J;Ortiz de Lejarazu Leonardo R;Eiros Bouza JM

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Background: vaccination is the best approach to prevent influenza infections so far. Serological studies on the effect of different vaccine types are important to address vaccination campaigns and protect our population. In our study, we compared the serological response against influenza A subtypes using the non-adjuvanted influenza vaccine (NAIV) in adults and the elderly and the adjuvanted influenza vaccine (AIV) in the elderly. Methods: We performed a retrospective analysis by hemagglutination inhibition assay (HI) of serum samples right before and 28 days after seasonal influenza vaccination during the 1996–2017 seasons. Conclusions: The AIV presents better performance against the A(H3N2) subtype in the elderly whereas the NAIV induces a better response against A(H1N1)pdm09 in the same group.
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