Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains.
Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains.
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DOI：
10.1038/s41467-021-21199-z
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发表时间：
2021-02-10
影响因子：
16.6
通讯作者：
Lambrechts L
中科院分区：
文献类型：
--
作者：
Aubry F;Jacobs S;Darmuzey M;Lequime S;Delang L;Fontaine A;Jupatanakul N;Miot EF;Dabo S;Manet C;Montagutelli X;Baidaliuk A;Gámbaro F;Simon-Lorière E;Gilsoul M;Romero-Vivas CM;Cao-Lormeau VM;Jarman RG;Diagne CT;Faye O;Faye O;Sall AA;Neyts J;Nguyen L;Kaptein SJF;Lambrechts L
寨卡病毒(ZIKV)的全球出现揭示了蚊媒病毒导致先天性出生缺陷的前所未有的能力。寨卡病毒出现的一个令人费解的方面是，迄今为止所有人类疫情和出生缺陷都完全与亚洲寨卡病毒血统有关，尽管越来越多的实验室证据表明非洲寨卡病毒血统具有更高的传播力和致病性。这一明显的悖论是否反映了在大多数实验室研究中使用相对较老的非洲ZIKV毒株，目前尚不清楚。在这里，我们对代表最近流行的病毒遗传多样性的七个低传代ZIKV毒株进行了实验比较。我们发现，最近的非洲ZIKV毒株在蚊子中表现出更高的传播率，在成年和胚胎小鼠中的致死率都高于亚洲同行。我们强调非洲ZIKV毒株的高流行潜力，并建议它们比亚洲毒株更容易被公共卫生监测系统注意到，因为它们容易导致胎儿丧失而不是出生缺陷。在这里，作者比较了7个低传代寨卡病毒(ZIKV)毒株，它们代表了最近流行的非洲和亚洲毒株的病毒遗传多样性，发现非洲ZIKV毒株在蚊子中具有更高的传播率，在成年和胚胎小鼠中都具有更高的致死率。
The global emergence of Zika virus (ZIKV) revealed the unprecedented ability for a mosquito-borne virus to cause congenital birth defects. A puzzling aspect of ZIKV emergence is that all human outbreaks and birth defects to date have been exclusively associated with the Asian ZIKV lineage, despite a growing body of laboratory evidence pointing towards higher transmissibility and pathogenicity of the African ZIKV lineage. Whether this apparent paradox reflects the use of relatively old African ZIKV strains in most laboratory studies is unclear. Here, we experimentally compare seven low-passage ZIKV strains representing the recently circulating viral genetic diversity. We find that recent African ZIKV strains display higher transmissibility in mosquitoes and higher lethality in both adult and fetal mice than their Asian counterparts. We emphasize the high epidemic potential of African ZIKV strains and suggest that they could more easily go unnoticed by public health surveillance systems than Asian strains due to their propensity to cause fetal loss rather than birth defects. Here, the authors compare seven low passage Zika virus (ZIKV) strains representing the recently circulating viral genetic diversity of African and Asian strains and find that African ZIKV strains have higher transmissibility in mosquitoes and higher lethality in both adult and fetal mice.
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影响因子：
3.8
作者：
Dowall SD;Graham VA;Rayner E;Atkinson B;Hall G;Watson RJ;Bosworth A;Bonney LC;Kitchen S;Hewson R
通讯作者：
Hewson R
影响因子：
3.8
作者：
Faye O;Freire CC;Iamarino A;Faye O;de Oliveira JV;Diallo M;Zanotto PM;Sall AA
通讯作者：
Sall AA
影响因子：
3.8
作者：
Aliota MT;Dudley DM;Newman CM;Mohr EL;Gellerup DD;Breitbach ME;Buechler CR;Rasheed MN;Mohns MS;Weiler AM;Barry GL;Weisgrau KL;Eudailey JA;Rakasz EG;Vosler LJ;Post J;Capuano S 3rd;Golos TG;Permar SR;Osorio JE;Friedrich TC;O'Connor SL;O'Connor DH
通讯作者：
O'Connor DH
DOI：
10.4269/ajtmh.17-0263
发表时间：
2017-11
期刊：
The American journal of tropical medicine and hygiene
影响因子：
--
作者：
Duggal NK;Ritter JM;McDonald EM;Romo H;Guirakhoo F;Davis BS;Chang GJ;Brault AC
通讯作者：
Brault AC
影响因子：
56.9
作者：
Aubry, Fabien;Dabo, Stephanie;Lambrechts, Louis
通讯作者：
Lambrechts, Louis