Self-protection strategies and health behaviour in patients with inflammatory rheumatic diseases during the COVID-19 pandemic: results and predictors in more than 12 000 patients with inflammatory rheumatic diseases followed in the Danish DANBIO registry.
Self-protection strategies and health behaviour in patients with inflammatory rheumatic diseases during the COVID-19 pandemic: results and predictors in more than 12 000 patients with inflammatory rheumatic diseases followed in the Danish DANBIO registry.
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DOI：
10.1136/rmdopen-2020-001505
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发表时间：
2021-01
期刊：
影响因子：
6.2
通讯作者：
Hetland M
中科院分区：
文献类型：
--
作者：
Glintborg B;Jensen DV;Engel S;Terslev L;Pfeiffer Jensen M;Hendricks O;Ostergaard M;Horskjær Rasmussen S;Adelsten T;Colic A;Danebod K;Kildemand M;Loft AG;Munk HL;Pedersen JK;Østgård RD;Møller Sørensen C;Krogh NS;Agerbo J;Ziegler C;Hetland M
在丹麦炎症性风湿病患者中开展研究，探讨自我保护策略和健康行为，包括在新冠肺炎大流行的初期阶段和协会重新开放后再次坚持疾病修改抗风湿治疗。此外，找出焦虑和自我隔离程度高的患者的特点。在全国DANBIO登记中对常规护理中的患者进行前瞻性跟踪调查的患者被邀请在2020年3月和6月回答一份关于疾病活动和新冠肺炎感染行为的在线问卷。回复与DANBIO中的患者数据相关联。用多因素Logistic回归分析探讨与焦虑、自我孤立和服药依从性(性别/年龄/诊断/教育/工作status/comorbidity/DMARD/smoking/EQ-5D/disease活动)相关的特征。我们纳入了12DMARD患者(8168例类风湿性关节炎/2068例银屑病关节炎/1758例中轴性脊柱炎/795例其他)，其中65%是女性，36%接受 治疗。自我报告的新冠肺炎患病率为0.3%。患者反映，他们担心感染新冠肺炎(3/6月份：70%/45%)，自我隔离比同龄人更多(48%/38%)。因害怕新冠肺炎而换药的患者比例为4.1%/0.6%。女性、合并症、不工作、低学历、生物治疗和欧洲人生活质量差5个维度与焦虑和自我孤立有关。在患有炎症性关节炎的>；12 000患者中，我们发现在新冠肺炎大流行的初始阶段，患者普遍存在焦虑和自我隔离，但药物依从性很高。在接下来的几个月里，随着社会的逐步开放，这种情况一直存在。在这次和未来可能的流行病中，关注患者的焦虑和自我隔离是很重要的。
In Danish patients with inflammatory rheumatic diseases to explore self-protection strategies and health behaviour including adherence to disease-modifying antirheumatic treatment (DMARD) during the initial phase of the COVID-19 pandemic and again after the reopening of the society started. Furthermore, to identify characteristics of patients with high levels of anxiety and self-isolation. Patients in routine care followed prospectively in the nationwide DANBIO registry were invited to answer an online questionnaire regarding disease activity and COVID-19 infection, behaviour in March and June 2020. Responses were linked to patient data in DANBIO. Characteristics potentially associated with anxiety, self-isolation and medication adherence (gender/age/diagnosis/education/work status/comorbidity/DMARD/smoking/EQ-5D/disease activity) were explored with multivariable logistic regression analyses. We included 12 789 patients (8168 rheumatoid arthritis/2068 psoriatic arthritis/1758 axial spondyloarthritis/795 other) of whom 65% were women and 36% treated with biological DMARD. Self-reported COVID-19 prevalence was 0.3%. Patients reported that they were worried to get COVID-19 infection (March/June: 70%/45%) and self-isolated more than others of the same age (48%/38%). The fraction of patients who changed medication due to fear of COVID-19 were 4.1%/0.6%. Female gender, comorbidities, not working, lower education, biological treatment and poor European Quality of life, 5 dimensions were associated with both anxiety and self-isolation. In >12 000 patients with inflammatory arthritis, we found widespread anxiety and self-isolation, but high medication adherence, in the initial phase of the COVID-19 pandemic. This persisted during the gradual opening of society during the following months. Attention to patients’ anxiety and self-isolation is important during this and potential future epidemics.
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