Voluntary wheel running attenuates ethanol withdrawal-induced increases in seizure susceptibility in male and female rats.
Voluntary wheel running attenuates ethanol withdrawal-induced increases in seizure susceptibility in male and female rats.
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自愿行驶的车轮会减弱乙醇提取引起的雄性和雌性大鼠的癫痫敏感性增加。
DOI：
10.1016/j.pbb.2012.07.012
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发表时间：
2012-11
影响因子：
3.6
通讯作者：
Rosenwasser, Alan M.
中科院分区：
文献类型：
--
作者：
Devaud, Leslie L.;Walls, Shawn A.;McCulley, Walter D., III;Rosenwasser, Alan M.
我们最近发现，自愿轮运行衰减乙醇戒断诱导的敏感性增加化学惊厥诱导的癫痫发作的雄性大鼠。由于雌性大鼠从乙醇戒断（EW）中恢复的速度比雄性大鼠更快，因此本研究旨在确定运动对EW癫痫发作的影响是否也表现出性别差异。将动物保持在无轮、锁定轮或自由轮条件下，并通过液体饮食给予乙醇14天，对照动物成对喂食等热量饮食，之后在EW的第1天或第3天测定癫痫发作阈值。与以前的报告一致，无论饮食条件如何，女性跑步明显多于男性。引入含乙醇的液体饮食大大增加了女性在白天（休息）阶段的跑步，对夜间活动影响不大。与以前的报告一致，EW增加癫痫发作的敏感性在1天的非运动的男性和女性，并在3天的男性。在两种性别中，这些影响都因使用转轮而减弱。我们还评估了性别，乙醇饮食和运动对乙醇清除率的影响后，急性乙醇管理1天EW在一个单独的一组动物。血液中的乙醇浓度在30分钟后注射较低的男性，乙醇暴露的动物，和跑步者，但没有这些因素之间的相互作用被检测到。有趣的是，女性比男性表现出更快的乙醇清除率，饮食或车轮访问对清除率没有影响。两者合计，这些数据表明，自愿轮运行乙醇管理期间提供了对EW癫痫发作的男性和女性的保护作用。在雄性大鼠（而非雌性大鼠）中，运动对早期药代动力学贡献的影响可能部分介导了该效应。这支持了鼓励酗酒者锻炼可能有利于他们康复的观点。
We recently found that voluntary wheel running attenuated ethanol withdrawal-induced increased susceptibility to chemoconvulsant-induced seizures in male rats. Since female rats recover from ethanol withdrawal (EW) more quickly than male rats across several behavioral measures, this study was designed to determine whether the effects of exercise on EW seizures also exhibited sex differences. Animals were maintained under No-Wheel, Locked-Wheel or Free-Wheel conditions and ethanol was administered by liquid diet for 14 days with control animals pair-fed an isocaloric diet, after which seizure thresholds were determined at 1 day or 3 days of EW. Consistent with previous reports, females ran significantly more than males, regardless of diet condition. Introduction of the ethanol-containing liquid diet dramatically increased running for females during the day (rest) phase, with little impact on night phase activity. Consistent with previous reports, EW increased seizure susceptibility at 1 day in non-exercising males and females and at 3 days in males. These effects were attenuated by access to running wheels in both sexes. We also assessed the effects of sex, ethanol diet and exercise on ethanol clearance following an acute ethanol administration at 1 day EW in a separate set of animals. Blood ethanol concentrations at 30 min post-injection were lower in males, ethanol-exposed animals, and runners, but no interactions among these factors were detected. Interestingly, females displayed more rapid ethanol clearance than males and there were no effects of either diet or wheel access on clearance rates. Taken together, these data suggest that voluntary wheel running during ethanol administration provides protective effects against EW seizures in both males and females. This effect may be mediated, in part, in male, but not female rat, by effects of exercise on early pharmacokinetic contributions. This supports the idea that encouraging alcoholics to exercise may benefit their recovery.
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影响因子：
2.7
作者：
Greenwood, Benjamin N.;Foley, Teresa E.;Le, Tony V.;Strong, Paul V.;Loughridge, Alice B.;Day, Heidi E. W.;Fleshner, Monika
通讯作者：
Fleshner, Monika
影响因子：
3.6
作者：
McCulley, Walter D., III;Walls, Shawn A.;Khurana, Ritu C.;Rosenwasser, Alan M.;Devaud, Leslie L.
通讯作者：
Devaud, Leslie L.
DOI：
10.1124/jpet.106.107896
发表时间：
2007-01-01
影响因子：
3.5
作者：
Alele, P. E.;Devaud, L. L.
通讯作者：
Devaud, L. L.
影响因子：
3.6
作者：
Koirala, Bikul;Alele, Paul E.;Devaud, Leslie L.
通讯作者：
Devaud, Leslie L.
影响因子：
3.5
作者：
Finn DA;Beckley EH;Kaufman KR;Ford MM
通讯作者：
Ford MM