Long-term voluntary wheel running is rewarding and produces plasticity in the mesolimbic reward pathway.
Long-term voluntary wheel running is rewarding and produces plasticity in the mesolimbic reward pathway.
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DOI：
10.1016/j.bbr.2010.11.005
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发表时间：
2011-03-01
影响因子：
2.7
通讯作者：
Fleshner, Monika
中科院分区：
文献类型：
--
作者：
Greenwood, Benjamin N.;Foley, Teresa E.;Le, Tony V.;Strong, Paul V.;Loughridge, Alice B.;Day, Heidi E. W.;Fleshner, Monika
关键词：
中脑边缘奖赏通路与压力相关的精神障碍有关，是反复自愿运动产生的压力抵抗力的潜在可塑性靶点。然而，目前尚不清楚大鼠是否发现长期接触跑步轮是有益的，或者重复的自愿运动奖励是否会在中脑边缘奖励神经回路中产生可塑性变化。在目前的研究中，年轻的成年雄性Fischer 344大鼠允许自愿进入转轮6周，但不是2周，发现转轮运行奖励，如条件性位置偏好（CPP）所测量的。与先前的报告和行为数据一致，6周的车轮运行增加了丘脑核（Acb）中的ΔFosB/FosB免疫反应性。此外，半定量原位杂交显示，6周的车轮运行，相比久坐不动的住房，增加酪氨酸羟化酶（TH）的mRNA水平在腹侧被盖区（VTA），增加δ阿片受体（DOR）的mRNA水平在Acb壳，并减少多巴胺受体（DR）-D2 mRNA水平在Acb核心。结果表明，反复自愿运动是有益的，并改变基因转录的中脑边缘奖励神经回路。轮跑对CPP的持续时间依赖效应表明，随着轮跑周数的增加，自愿轮跑的夜间奖励效应可能会持续更长时间，从而为CPP提供更强的支持。所观察到的可塑性可能有助于运动减少药物滥用障碍的发生率和严重程度，改变药物滥用的奖励性质，并促进成功应对压力的机制。
The mesolimbic reward pathway is implicated in stress-related psychiatric disorders and is a potential target of plasticity underlying the stress resistance produced by repeated voluntary exercise. It is unknown, however, whether rats find long-term access to running wheels rewarding, or if repeated voluntary exercise reward produces plastic changes in mesolimbic reward neurocircuitry. In the current studies, young adult, male Fischer 344 rats allowed voluntary access to running wheels for 6 weeks, but not 2 weeks, found wheel running rewarding, as measured by conditioned place preference (CPP). Consistent with prior reports and the behavioral data, 6 weeks of wheel running increased ΔFosB/FosB immunoreactivity in the nucleus accumbens (Acb). In addition, semi quantitative in situ hybridization revealed that 6 weeks of wheel running, compared to sedentary housing, increased tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area (VTA), increased delta opioid receptor (DOR) mRNA levels in the Acb shell, and reduced levels of dopamine receptor (DR)-D2 mRNA in the Acb core. Results indicate that repeated voluntary exercise is rewarding and alters gene transcription in mesolimbic reward neurocircuitry. The duration-dependent effects of wheel running on CPP suggest that as the weeks of wheel running progress, the rewarding effects of a night of voluntary wheel running might linger longer into the inactive cycle thus providing stronger support for CPP. The observed plasticity could contribute to the mechanisms by which exercise reduces the incidence and severity of substance abuse disorders, changes the rewarding properties of drugs of abuse, and facilitates successful coping with stress.
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影响因子：
2.7
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通讯作者：
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