The effects of focal articular defects on cartilage contact mechanics.
The effects of focal articular defects on cartilage contact mechanics.
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DOI：
10.1002/jor.20762
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发表时间：
2009-05
影响因子：
2.8
通讯作者：
Sah, Robert L.
中科院分区：
文献类型：
--
作者：
Gratz, Kenneth R.;Wong, Benjamin L.;Bae, Won C.;Sah, Robert L.
关节软骨的局灶性损伤在关节镜检查患者中很常见，并可能通过改变局部机械环境而导致进行性组织退变。局灶性缺损处相对于软骨下骨可能朝向不同的方向，对软骨接触和变形的动力学影响尚不清楚。本研究的目的是阐明实验性全层局灶性缺损在压缩和应力松弛过程中对相对软骨表面的组织内应变和表面滑移的影响。对完整的牛骨软骨块进行20%的单轴压缩，并允许应力松弛。用视频显微镜记录组织变形情况。在每对中的一个块中创建全厚度缺陷(具有80°或100°边缘)。允许积木重新膨胀并重新测试。然后用相反的方向重新切割缺陷边缘，允许重新膨胀，并再次测试。通过数字图像相关跟踪染色的细胞核，并用于量化软骨应变和表面滑动。结果表明，完整试件的加载引起的轴向应变值随着深度的增加而减小，滑动相对较小。随着含有缺陷的样本的加载，邻近和相对缺陷的软骨中的应变量增加。对于边缘取向为100°的样品，在与缺陷相邻的表面上滑移幅度增大。这些由全层关节软骨缺陷引起的局部力学变化可能导致软骨细胞代谢改变、组织损伤或加速磨损。
Focal damage to articular cartilage is common in arthroscopy patients and may contribute to progressive tissue degeneration by altering the local mechanical environment. The effects of a focal defect, which may be oriented at various orientations relative to the subchondral bone, on the dynamics of cartilage contact and deformation are unclear. The objective of this study was to elucidate the effect of experimental full thickness focal defects, oriented at 80° or 100° relative to the subchondral bone, on intra-tissue strain and surface sliding of opposing cartilage surfaces during compression and stress relaxation. Pairs of intact bovine osteochondral blocks were compressed uniaxially by 20%, and allowed to stress relax. Tissue deformation was recorded by video microscopy. A full-thickness defect (with either 80° or 100° edges) was created in one block from each pair. Blocks were allowed to re-swell and retested. Defect edges were then re-cut with the opposite orientation, allowed to re-swell, and retested again. Stained nuclei were tracked by digital image correlation and used to quantify cartilage strains and surface sliding. The results indicated that loading of intact samples caused axial strain magnitudes that decreased with depth and relatively little sliding. With loading of samples containing defects, strain magnitudes were elevated in cartilage adjacent to, and opposing, defects. For samples with edge orientations of 100°, sliding magnitudes were increased over surfaces adjacent to defects. These local mechanical changes due to full-thickness articular cartilage defects may contribute to altered chondrocyte metabolism, tissue damage, or accelerated wear.
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DOI：
10.1053/jars.2002.32839
发表时间：
2002-09-01
影响因子：
4.7
作者：
Hjelle, K;Solheim, E;Brittberg, M
通讯作者：
Brittberg, M
DOI：
10.1016/s0749-8063(97)90124-9
发表时间：
1997-08-01
影响因子：
4.7
作者：
Curl, WW;Krome, J;Poehling, GG
通讯作者：
Poehling, GG
影响因子：
2.4
作者：
Gratz, Kenneth R.;Sah, Robert L.
通讯作者：
Sah, Robert L.
影响因子：
5
作者：
LIPSHITZ, H;GLIMCHER, MJ
通讯作者：
GLIMCHER, MJ
影响因子：
2.4
作者：
Klein, Travis J.;Chaudhry, Manu;Sah, Robert L.
通讯作者：
Sah, Robert L.