Breast cancer: a neglected disease for the majority of affected women worldwide.
Breast cancer: a neglected disease for the majority of affected women worldwide.
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DOI：
10.1111/j.1524-4741.2011.01067.x
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Love RR
中科院分区：
文献类型：
--
作者：
Ginsburg OM;Love RR
最近一些高收入国家死亡率下降的进展掩盖了这样一个事实，即对于世界上大多数新诊断的妇女来说，乳腺癌是一种被忽视的疾病，与其他在数字上更常见的健康问题相比。对于这一日益增长的大多数人来说，它也是一种孤儿病，因为缺乏关于肿瘤特征和相关宿主生物学的详细知识，这些知识甚至是提供基本护理所必需的。目前的国际癌症政策和规划倡议与乳腺癌无关，营养建议可能是个例外。在高收入国家取得的进展是以巨大的财政开支和患者毒性为代价的，这本身就表明与中低收入国家的妇女和保健从业人员无关。这些情况的影响似乎很清楚：如果要在乳腺癌问题上实现60年前的《人权宣言》的承诺，即医学科学的成果将惠及全人类，就应该发起一项基础性和转化性的全球研究倡议。
Recent progress with declines in mortality in some high income countries has obscured the fact that for the majority of women worldwide who are newly diagnosed, breast cancer is a neglected disease in the context of other numerically more frequent health problems. For this growing majority, it is also an orphan disease, in that detailed knowledge about tumor characteristics and relevant host biology necessary to provide even basic care are absent. With the possible exception of nutritional recommendations, current international cancer policy and planning initiatives are irrelevant to breast cancer. The progress that has occurred in high income countries has come at extraordinary fiscal expense and patient toxicity, which of themselves suggest non-relevance to women and health care practitioners in middle and low income countries. The implications of these circumstances seem clear: if the promise of the now 60 year-old Declaration of Human Rights, that the fruits of medical science accrue to all mankind, is to be realized with respect to breast cancer, a basic and translational global research initiative should be launched.
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女性乳腺癌发病率和死亡率的全球模式不断变化。
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