Gastric epithelial stem cells.
Gastric epithelial stem cells.
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DOI：
10.1053/j.gastro.2010.12.001
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发表时间：
2011-02
期刊：
影响因子：
29.4
通讯作者：
Shivdasani RA
中科院分区：
文献类型：
--
作者：
Mills JC;Shivdasani RA
我们对胃肠道干细胞的认识的进展包括小肠中干细胞和早期祖细胞的分子标记的鉴定。虽然胃上皮干细胞已经定位，但对其分子生物学知之甚少。最近的报道描述了使用可诱导的Cre重组酶活性来标记远端胃（即胃窦和幽门）的候选干细胞及其后代。在胃体（体）中没有上皮干细胞的谱系标记的报道。在消化道的干细胞中，成体的干细胞是独特的，因为它们靠近管腔，在失去一个成熟的后代谱系，即分泌酸的壁细胞后，它们会增加增殖。它们的独特之处在于它们既不依赖于Wnt信号，也不表达表面标记物Lgr5。由于胃腺癌的发病机制与胃分化模式异常和慢性组织损伤有关，因此对胃上皮干细胞对炎症的反应进行了大量研究。由幽门螺杆菌感染引起的慢性炎症影响分化并促进化生。一些研究已经确定了表达痉挛性多肽（假幽门）化生的细胞和分子机制。研究人员也开始确定胚胎发育过程中发生的信号通路和事件，这些信号通路和事件最终建立成体干细胞以维持胃粘膜的特定特征和功能。我们综述了胃上皮干细胞的细胞学、分子、功能和发育特性。
Advances in our understanding of stem cells in the gastrointestinal tract include the identification of molecular markers of stem and early progenitor cells in the small intestine. Although gastric epithelial stem cells have been localized, little is known about their molecular biology. Recent reports describe the use of inducible Cre recombinase activity to indelibly label candidate stem cells and their progeny in the distal stomach, (ie, the antrum and pylorus). No such lineage labeling of epithelial stem cells has been reported in the gastric body (corpus). Among stem cells in the alimentary canal, those of the adult corpus are unique in that they lie close to the lumen and increase proliferation following loss of a single mature progeny lineage, the acid-secreting parietal cell. They are also unique in that they neither depend on Wnt signaling nor express the surface marker Lgr5. Because pathogenesis of gastric adenocarcinoma has been associated with abnormal patterns of gastric differentiation and with chronic tissue injury, there has been much research on the response of stomach epithelial stem cells to inflammation. Chronic inflammation, as induced by infection with Helicobacter pylori, affects differentiation and promotes metaplasias. Several studies have identified cellular and molecular mechanisms in spasmolytic polypeptide–expressing (pseudopyloric) metaplasia. Researchers have also begun to identify signaling pathways and events that take place during embryonic development that eventually establish the adult stem cells to maintain the specific features and functions of the stomach mucosa. We review the cytologic, molecular, functional, and developmental properties of gastric epithelial stem cells.
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胃上皮祖细胞生态位和酶原（主要）细胞谱系的分化。
影响因子：
2.7
作者：
Bredemeyer, Andrew J.;Geahlen, Jessica H.;Weis, Victoria G.;Huh, Won Jae;Zinselmeyer, Bernd H.;Srivatsan, Subhashini;Miller, Mark J.;Shaw, Andrey S.;Mills, Jason C.
通讯作者：
Mills, Jason C.
影响因子：
--
作者：
CORPRON, RE
通讯作者：
CORPRON, RE
影响因子：
--
作者：
KARAM, SM;LEBLOND, CP
通讯作者：
LEBLOND, CP
DOI：
10.1073/pnas.93.6.2431
发表时间：
1996-03-19
影响因子：
11.1
作者：
Canfield, V;West, AB;Levenson, R
通讯作者：
Levenson, R
影响因子：
4.8
作者：
Giannakis, M;Stappenbeck, TS;Gordon, JI
通讯作者：
Gordon, JI