Frequency-dependent functional connectivity of the nucleus accumbens during continuous transcutaneous vagus nerve stimulation in major depressive disorder.
Frequency-dependent functional connectivity of the nucleus accumbens during continuous transcutaneous vagus nerve stimulation in major depressive disorder.
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DOI：
10.1016/j.jpsychires.2017.12.018
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发表时间：
2018-07
影响因子：
4.8
通讯作者：
Kong J
中科院分区：
文献类型：
--
作者：
Wang Z;Fang J;Liu J;Rong P;Jorgenson K;Park J;Lang C;Hong Y;Zhu B;Kong J
经皮迷走神经刺激（tVNS）可能是一种有前途的治疗抑郁症（MDD）。在这项探索性研究中，41名MDD患者在连续真实的或假tVNS期间获得fMRI扫描。然后，所有患者接受为期四周的真实的或假tVNS治疗。我们研究了真实的和假tVNS过程中不同频段的延髓核（NAc）的功能连接（FC），并探讨了它们与治疗一个月后抑郁症状变化的关系。结果显示：（1）在连续真实的和假tVNS时，NAc与周围区域（包括壳核、尾状核、内侧前额叶皮层（MPFC）和前扣带皮层（ACC））之间均存在明显的FC阳性反应; 2）与假tVNS相比，真实的tVNS使左侧NAc和双侧MPFC/rACC之间慢5频段的FC增加（0.008-0.027），在典型低频带，右侧NAc与左侧枕叶、枕回和右侧舌/梭状回之间（0.008-0.09）;（3）治疗1个月后，tVNS组NAc-MPFC/rACC的FC与汉密尔顿评分呈负相关，而假手术组无相关性。我们的研究结果表明，tVNS可以调制低频内在FC的关键脑区参与奖励和动机的处理，并提供洞察的大脑机制tVNS治疗MDD。
Transcutaneous vagus nerve stimulation (tVNS) may be a promising treatment for major depressive disorder (MDD). In this exploratory study, fMRI scans were acquired during continuous real or sham tVNS from 41 MDD patients. Then, all patients received real or sham tVNS treatments for four weeks. We investigated the functional connectivity (FC) of the nucleus accumbens (NAc) at different frequency bands during real and sham tVNS and explored their associations with depressive symptom changes after one month treatments. The results revealed: 1) during continuous real and sham tVNS there are significant positive FC between the NAc and surrounding areas including the putamen, caudate, and distinct areas of the medial prefrontal cortex (MPFC) and the anterior cingulate cortex (ACC); 2) compared with sham tVNS, real tVNS increased the FC between the left NAc and bilateral MPFC/rACC in the slow-5 band(0.008–0.027) and between the right NAc and left insula, occipital gyrus, and right lingual / fusiform gyrum in the typical low band (0.008–0.09); and 3) the FC of the NAc-MPFC/rACC during real tVNS showed a negative association with Hamilton Depression Rating Scale (HAMD) score changes in the real tVNS group after one month treatment, but not in the sham group. Our findings demonstrate that tVNS can modulate low frequency intrinsic FC among key brain regions involved in reward and motivation processing, and provide insights into the brain mechanism underlying tVNS treatment of MDD.
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DOI：
10.1016/j.nicl.2016.12.016
发表时间：
2017
期刊：
NeuroImage. Clinical
影响因子：
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作者：
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作者：
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通讯作者：
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影响因子：
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作者：
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