Nucleus accumbens, thalamus and insula connectivity during incentive anticipation in typical adults and adolescents.
Nucleus accumbens, thalamus and insula connectivity during incentive anticipation in typical adults and adolescents.
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DOI：
10.1016/j.neuroimage.2012.10.013
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发表时间：
2013-02-01
期刊：
影响因子：
5.7
通讯作者：
Ernst, Monique
中科院分区：
文献类型：
--
作者：
Cho, Youngsun T.;Fromm, Stephen;Guyer, Amanda E.;Detloff, Allison;Pine, Daniel S.;Fudge, Julie L.;Ernst, Monique
奖励神经回路将动机与复杂的行为反应联系起来。对激励处理的研究已经反复证明了奖励神经回路的三个关键组成部分--丘脑和前丘脑的激活。丘脑对人类这一电路的贡献相对被忽视，考虑到该结构在处理和过滤信息方面的核心作用，这一空白需要填补。本研究旨在了解这三个区域在成人和青年的收益或损失预期中如何作为网络发挥作用。为了实现这一目标，功能性磁共振成像（fMRI）和动态因果模型（DCM）被用来检查这三个节点之间的有效连接在健康的成年人和青少年谁执行的金钱激励延迟（MID）的任务。七个连接模型，解剖连接的基础上，进行了测试。他们估计激励预期和贝叶斯模型选择（BMS），以确定最适合的模型为每个成人和青少年组。从最佳拟合模型中提取连接强度，并检查各组的显著性。然后将这些变量输入线性混合模型，以测试组间对奖励神经回路有效连接的影响。两组的最佳拟合模型包括所有可能的解剖连接。得出了三个主要结论：（1）在整个任务中，丘脑和丘脑显著影响NAc;（2）在两组中，丢失线索条件下的显著连接比获得线索条件下的显著连接更广泛;（3）最后，连接强度的组间比较未能检测到统计学差异，表明成年人和青少年以类似的方式使用这种激励处理网络。这项研究表明，在人类的激励过程中，丘脑和丘脑影响NAc的方式。具体来说，这是第一个研究证明在人类中丘脑投射到NAc的关键作用，以支持奖励处理。我们的研究结果表明，预期的收益/损失涉及一个“报警”信号（丘脑），收敛与内感受性信息（ESTA），以形成行动选择程序在腹侧纹状体。
Reward neurocircuitry links motivation with complex behavioral responses. Studies of incentive processing have repeatedly demonstrated activation of nucleus accumbens (NAc), thalamus, and anterior insula, three key components of reward neurocircuitry. The contribution of the thalamus to this circuitry in humans has been relatively ignored, a gap that needs to be filled, given the central role of this structure in processing and filtering information. This study aimed to understand how these three regions function as a network during gain or loss anticipation in adults and youth. Towards this goal, functional magnetic resonance imaging (fMRI) and dynamic causal modeling (DCM) were used to examine effective connectivity among these three nodes in healthy adults and adolescents who performed the monetary incentive delay (MID) task. Seven connectivity models, based on anatomic connections, were tested. They were estimated for incentive anticipation and underwent Bayesian Model Selection (BMS) to determine the best-fit model for each adult and adolescent group. Connection strengths were extracted from the best-fit model and examined for significance in each group. These variables were then entered into a linear mixed model to test between-group effects on effective connectivity in reward neurocircuitry. The best-fit model for both groups included all possible anatomic connections. Three main findings emerged: (1) Across the task, thalamus and insula significantly influenced NAc; (2) A broader set of significant connections was found for the loss-cue condition than the gain-cue condition in both groups; (3) Finally, between-group comparisons of connectivity strength failed to detect statistical differences, suggesting that adults and adolescents use this incentive-processing network in a similar manner. This study demonstrates the way in which the thalamus and insula influence the NAc during incentive processing in humans. Specifically, this is the first study to demonstrate in humans the key role of thalamus projections onto the NAc in support of reward processing. Our results suggest that anticipation of gain/loss involves an ‘alerting’ signal (thalamus) that converges with interoceptive information (insula) to shape action selection programs in the ventral striatum.
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