Rhodamine-B decorated superparamagnetic iron oxide nanoparticles: preparation, characterization and their optical/magnetic properties
Rhodamine-B decorated superparamagnetic iron oxide nanoparticles: preparation, characterization and their optical/magnetic properties
复制标题
罗丹明-B 修饰的超顺磁性氧化铁纳米粒子：制备、表征及其光/磁性能
DOI：
10.1039/c1jm12353j
复制
发表时间：
2011-10
影响因子：
--
通讯作者：
Xian, Yuezhong
中科院分区：
文献类型：
--
作者：
Shi, Xinhao;Zhang, Yixuan;Zhang, Wenjing;Liang, Cong;Xian, Yuezhong
通过铜(I)催化Huisgen叠氮化物-炔1,3-偶极环加成（CuAAC）反应，报道了端叠氮基罗丹明- b （RhB）与端炔硅包覆超顺磁性氧化铁纳米粒子的共价键合反应。采用粉末x射线衍射（XRD）、透射电子显微镜（TEM）、傅里叶变换红外光谱（FTIR）、荧光显微镜和磁学对反应过程进行了跟踪。RhB标记的Fe3O4@SiO2纳米颗粒表现出稳定的荧光，没有检测到荧光染料的泄漏，因为通过点击反应形成的1,4-二取代1,2,3-三唑环是热稳定的，对水解，氧化和还原相对惰性。由于Fe3O4和RhB分子在Fe3O4@SiO2框架中共价修饰的超顺磁性，使得纳米颗粒在磁共振成像（MRI）和光学成像模式下具有造影剂的性质。细胞毒性试验表明，该双功能纳米颗粒可用于生物医学或生物工程领域。
The paper reports on covalent clicking of rhodamine-B (RhB) bearing a terminal azide group to alkyne-terminated silica coated superparamagnetic iron oxide nanoparticlesvia the copper(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition (CuAAC) reaction. The course of the reaction was followed the use of powder X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, fluoroscopy, and magnetics. The RhB labelled Fe3O4@SiO2 nanoparticles exhibit stable fluorescence and no detectable leakage of the fluorescent dye because the resulting 1,4-disubstituted 1,2,3-triazole ring formed via click reaction is thermally stable and relatively inert to hydrolysis, oxidation, and reduction. Due to the superparamagnetic property of the Fe3O4 and the RhB molecule covalently decorated in the Fe3O4@SiO2 framework, the nanoparticles are endowed with properties of a contrast agent in magnetic resonance imaging (MRI) and optical imaging modality. The cytotoxicity tests indicate the bifunctional nanoparticles could be applied in biomedical or bioengineering field.
登录
查看更多内容
影响因子：
4.9
作者：
L. Polito;D. Monti;E. Caneva;Eleonora Delnevo;G. Russo;D. Prosperi
通讯作者：
L. Polito;D. Monti;E. Caneva;Eleonora Delnevo;G. Russo;D. Prosperi
影响因子：
17.1
作者：
Chandra, Vimlesh;Park, Jaesung;Kim, Kwang S.
通讯作者：
Kim, Kwang S.
影响因子：
8.6
作者：
A. Schaetz;R. Grass;Quirin M. Kainz;W. Stark;O. Reiser
通讯作者：
A. Schaetz;R. Grass;Quirin M. Kainz;W. Stark;O. Reiser
影响因子：
3.7
作者：
He, YP;Miao, YM;Burda, C
通讯作者：
Burda, C
影响因子：
8.6
作者：
Hayashi, Koichiro;Moriya, Makoto;Yogo, Toshinobu
通讯作者：
Yogo, Toshinobu