Clinical value of baseline (18)F-FDG PET/CT in soft tissue sarcomas.
Clinical value of baseline (18)F-FDG PET/CT in soft tissue sarcomas.
复制标题
软组织肉瘤中基线（18）F-FDG PET/CT的临床值。
DOI：
10.1186/s41824-021-00110-5
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发表时间：
2021-09-03
影响因子：
1.7
通讯作者：
Claver Valderas MA
中科院分区：
文献类型：
--
作者：
Reyes Marlés RH;Navarro Fernández JL;Puertas García-Sandoval JP;Santonja Medina F;Mohamed Salem L;Frutos Esteban L;Contreras Gutiérrez JF;Castellón Sánchez MI;Ruiz Merino G;Claver Valderas MA
18F-FDG正电子发射断层扫描/计算机断层扫描（PET/CT）在许多癌症的初始分期中的应用已明确确立。大多数软组织肉瘤（STS）对18F-FDG有很高的亲和力，这就是为什么18F-FDG PET/CT被认为是一种非侵入性的方法，在诊断和随访中很有用。标准化摄取值（SUV）、基于体积的代谢参数MTV（代谢肿瘤体积）和TLG（总病变糖酵解）确定肿瘤活力并提供其总体积和代谢活性肿瘤细胞的总活性。组织学分级是与STS相关的转移和死亡率的最重要预测因子，并且已经描述了18F-FDG PET/CT的代谢参数与组织学分级之间的显著关系。对STS患者进行了一项回顾性研究，根据FNCLCC（Fédération Nationale des Centres de Lutte Contre Le Cancer）标准进行了组织学分级，并进行了基线PET/CT检查。对SUV（SUV最大值、SUV平均值和SUV峰值）、MTV和TLG进行定量。进行T-student检验以建立代谢生物标志物与组织学分级之间的关系。使用受试者操作特征（ROC）曲线验证其作为组织学分级预测因子的有用性。使用Kaplan-Meier方法进行生存函数研究。为了评估代谢生物标志物的预后效用，我们使用对数秩方法。SUV值有助于区分高级别STS。我们发现组织学分级和SUV值之间存在显著相关性。SUVmax、SUVpeak、MTV和TLG是总生存期（OS）的预测因子。SUV平均值的OS或SUV最大值、SUV平均值、SUV峰值、MTV和TLG的无病生存期（DFS）无显著差异。SUVmax、SUVmean和SUVpeak值与HG相关，可用于区分高级别STS和低级别STS。具有高SUVmax、SUVpeak、MTV和TLG的患者具有显著较低的OS。
The use of 18F-FDG Positron emission tomography/Computed tomography (PET/CT) in the initial staging of many cancers is clearly established. Most soft tissue sarcoma (STS) has a high affinity for 18F-FDG, which is why 18F-FDG PET/CT has been proposed as a non-invasive method, useful in diagnosis and follow-up. The standardized uptake value values (SUV), the volume-based metabolic parameters MTV (metabolic tumor volume), and TLG (total lesion glycolysis) determine tumor viability and provide its total volume and the total activity of metabolically active tumor cells. The histological grade is the most important predictor of metastases and mortality associated with STS, and a significant relationship between the metabolic parameters of 18F-FDG PET/CT and the histological grade has been described. A retrospective study was conducted on STS patients, who had histological grade according to the FNCLCC (Fédération Nationale des Centres de Lutte Contre Le Cancer) criteria, as well as a baseline PET/CT. SUV (SUVmax, SUVmean, and SUVpeak), MTV, and TLG were quantified. A T-student test was performed to establish the relationship between the metabolic biomarkers and the histological grade. Their usefulness as predictors of the histological grade was verified using receiver operator characteristic (ROC) curves. A survival function study was performed using the Kaplan–Meier method. To assess the prognostic utility of the metabolic biomarkers we use the Log-Rank method. The SUV values were useful to discriminate high-grade STS. We found a significant relationship between the histological grade and the SUV values. SUVmax, SUVpeak, MTV, and TLG were predictors of overall survival (OS). There were no significant differences in the OS for the SUVmean, or in the disease-free survival (DFS) for SUVmax, SUVmean, SUVpeak, MTV, and TLG. The SUVmax, SUVmean, and SUVpeak values correlate with the HG and are useful to discriminate high-grade from low-grade STS. Patients with high SUVmax, SUVpeak, MTV, and TLG have a significantly lower OS.
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影响因子：
2.1
作者：
Hong, Sun-pyo;Lee, Seung Eun;Choi, Joon Young
通讯作者：
Choi, Joon Young
影响因子：
9.3
作者：
Benz, Matthias R.;Allen-Auerbach, Martin S.;Weber, Wolfgang A.
通讯作者：
Weber, Wolfgang A.
影响因子：
4
作者：
Corey, Robert M.;Swett, Katrina;Ward, William G.
通讯作者：
Ward, William G.
DOI：
10.1053/j.sult.2010.10.001
发表时间：
2010-12
期刊：
Seminars in ultrasound, CT, and MR
影响因子：
--
作者：
Kinahan PE;Fletcher JW
通讯作者：
Fletcher JW
影响因子：
6
作者：
Esperança-Martins M;Fernandes I;Soares do Brito J;Macedo D;Vasques H;Serafim T;Costa L;Dias S
通讯作者：
Dias S